Method for preparing 6-methylnicotinic acid etoricoxib intermediate and ester thereof
A technology for etoricoxib and intermediates, applied in the field of preparation of etoricoxib intermediate 6-methyl nicotinic acid and its esters, can solve the problems of low yield, high temperature and high pressure, long reaction time, etc. The effect of simplicity and mild reaction conditions
Active Publication Date: 2010-08-25
SHANGHAI HISOAR PHARMA TECH & DEV CO LTD +1
View PDF5 Cites 16 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
In short, to produce 6-methylnicotinic acid and its esters using the above-mentioned technology of using 2-methyl-6-ethylpyridine as the raw material, the main equipment is mostly made of titanium alloy with excellent anti-corrosion performance and relatively expensive price, and the reaction time Harsh conditions such as long, low yield or high temperature and high pressure are required, and there is a big problem of potential safety hazards, so a new method for preparing 6-methylnicotinic acid and its esters suitable for industrial production is needed in this area
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
Embodiment 2
Embodiment 3
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more PUM
Login to view more Abstract
The invention relates to a method for preparing 6-methylnicotinic acid etoricoxib intermediate and an ester thereof. The preparation method comprises halogenations, hydrolysis reaction and reducing dehalogenation. The method of the invention is simple in production process and mild in reaction conditions and is suitable for commercial production.
Description
A new method for preparing etorocoxib intermediate-6-methylnicotinic acid and its esters Technical field The present invention belongs to the field of intermediate synthesis of etoricoxib, and particularly relates to a preparation method for synthesizing etoricoxib intermediate 6-methylnicotinic acid and its esters. Background technique Etocoxib is a COX-2 inhibitor developed by Merck. It is mainly used for anti-inflammatory and analgesic clinical applications. Patent WO9955830 (Chinese patent ZL99807550.7) discloses a process for synthesizing etorocoxib through methyl 6-methylnicotinate or 6-methylnicotinic acid. The existing method for synthesizing 6-methylnicotinic acid uses 2-methyl-5-ethylpyridine as a raw material and is prepared by oxidation of potassium permanganate, nitric acid, or ozone and oxygen. Using potassium permanganate process [Chinese Journal of Pharmaceutical Industry, 36(5), 266-267; 2005] to prepare 6-methylnicotinic acid, 3.9kg potassium permanganate an...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more Application Information
Patent Timeline
Login to view more Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/80C07D213/803
Inventor 唐鹤苑文秋吴波
Owner SHANGHAI HISOAR PHARMA TECH & DEV CO LTD
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Try Eureka
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap