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Application of isothiocyanate to preparation of medicine for preventing and treating medicine-resistance tumor

A technology of isothiocyanate and benzyl isothiocyanate, which is applied in the field of preparation of isothiocyanate to prevent and treat drug-resistant tumor drugs

Active Publication Date: 2010-09-08
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The role of isothiocyanates in the prevention and treatment of drug-resistant tumors has not been reported

Method used

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  • Application of isothiocyanate to preparation of medicine for preventing and treating medicine-resistance tumor
  • Application of isothiocyanate to preparation of medicine for preventing and treating medicine-resistance tumor
  • Application of isothiocyanate to preparation of medicine for preventing and treating medicine-resistance tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The purposes of benzyl isothiocyanate in the preparation prevention and treatment resistant tumor drug, the molecular formula of benzyl isothiocyanate (BITC) is C 6 h 5 CH 2 NCS; the structural formula is:

[0042]

[0043] The drug-resistant tumor is drug-resistant lung cancer, drug-resistant liver cancer, drug-resistant esophageal cancer, drug-resistant gastric cancer, drug-resistant colon cancer, drug-resistant pancreatic cancer, drug-resistant breast cancer, drug-resistant cervical cancer, drug-resistant ovarian cancer, drug-resistant Prostate cancer, drug-resistant penile cancer, drug-resistant melanoma, drug-resistant brain tumor, drug-resistant oral cancer, drug-resistant ear cancer, drug-resistant nasopharyngeal cancer, and / or drug-resistant tongue cancer.

Embodiment 2

[0045] The purposes of phenylethyl isothiocyanate in the preparation prevention and treatment of tumor drug resistance, the molecular formula of phenylethyl isothiocyanate (PEITC) is C 6 h 5 CH 2 CH 2 NCS; the structural formula is:

[0046]

[0047] The drug-resistant tumor is drug-resistant lung cancer, drug-resistant liver cancer, drug-resistant esophageal cancer, drug-resistant gastric cancer, drug-resistant colon cancer, drug-resistant pancreatic cancer, drug-resistant breast cancer, drug-resistant cervical cancer, drug-resistant ovarian cancer, drug-resistant Prostate cancer, drug-resistant penile cancer, drug-resistant melanoma, drug-resistant brain tumor, drug-resistant oral cancer, drug-resistant ear cancer, drug-resistant nasopharyngeal cancer, and / or drug-resistant tongue cancer.

[0048] Benzyl isothiocyanate and phenylethyl isothiocyanate are added with pharmaceutically acceptable excipients to make various dosage forms according to conventional methods, suc...

Embodiment 3

[0051] Isothiocyanates inhibit the growth of multiple drug-resistant tumor cells

[0052] We selected human lung cancer cisplatin (cisplatin) sensitive cell line A549 and cisplatin resistant cell line A549 / DDP, and human lung cancer gefitinib (Gifitinib) sensitive cell line PC9 and gefitinib resistant cell line PC9 / AB2 , through the MTT method, it was found that BITC and PEITC can effectively inhibit the growth of sensitive and drug-resistant cells, especially the growth inhibitory effect on cisplatin-resistant cells A549 / DDP (IC 50 Respectively 8.8μM and 13.7μM) than cisplatin-sensitive cell A549 (IC 50 14.1 μM and 17.6 μM, respectively) were stronger, indicating a selective inhibitory effect on drug-resistant cells. The medium growth inhibitory concentrations are shown in Table 1. Figure 1-Figure 4 is the dose-growth curve of BITC inhibiting cell growth. Figure 5-Figure 8 is the dose-growth curve of PEITC inhibiting cell growth.

[0053] Table 1 isothiocyanates inhibit...

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PUM

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Abstract

The invention discloses application of isothiocyanate to the preparation of medicine for preventing and treating medicine-resistance tumor. The invention uses a celluar and molecular biology method for proving that the isothiocyanate can effectively inhabit the growth of medicine-resistance tumor cells, induce the apoptosis, regulate and control the tumor medicine-resistance relevant genes, cause medicine-resistance tumor cell cycle arrest, and cause tumor cell oxidative damage. Thereby, the isothiocyanate can be used as a active ingredient for preparing the medicine for preventing and treating medicine-resistance tumor, and food, health-care products and cosmetics for preventing and treating medicine-resistance tumor.

Description

technical field [0001] The invention belongs to the field of medical applications, and relates to the application of isothiocyanates in the preparation of drugs for preventing and treating drug-resistant tumors. Background technique [0002] The morbidity and mortality of cancer in my country are on the rise rapidly. Cancer has caused great suffering to patients and their families, and has taken up a lot of social resources and wealth. Cancer has become an increasingly serious public health problem facing mankind. Governments of various countries have invested a lot of human and material resources in order to make breakthroughs in the field of cancer research. [0003] At present, the main treatment methods for cancer are surgery, radiotherapy, chemotherapy and biological therapy. Surgical treatment is the most effective treatment. However, the vast majority of patients are already in the middle or late stage when they see a doctor, and they miss the opportunity for surgi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/26A61P35/00
Inventor 徐克周清华闫慧琴刘博宁吴骧
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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