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Cefepime hydrochloride combined medicament

A technology of cefepime hydrochloride and cefepime hydrochloride, which is applied in the field of cefepime hydrochloride combined drugs, can solve the problems of unstable storage, drug thermal reaction, drug allergy, etc., achieve complete sterilization, reduce pyrogen reaction, and improve drug quality high effect

Active Publication Date: 2010-09-08
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing cefepime hydrochloride injection is not stable when stored at room temperature, and there are drug allergies and adverse reactions to the gastrointestinal tract, liver, kidney, and blood system, as well as drug thermal reactions, intravenous infusion pain, and phlebitis. Adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The cefamandole sodium combination medicine provided by the invention is made up of following medicinal composition weight ratio:

[0027] Cefepime Hydrochloride 500

[0028] Lidocaine 100

[0029] Reduced Glutathione 50

[0030] Vitamin C 200

[0031] Cefepime hydrochloride may be replaced by cefepime hydrochloride, and the weight ratio is calculated by the weight of cefepime hydrochloride.

[0032] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0033] 1. Dissolve cefepime hydrochloride, lidocaine, reduced glutathione, and vitamin C with water for injection 50-200 times the weight of cefepime hydrochloride under normal speed stirring to obtain cefepime hydrochloride Oxime combination drug solution;

[0034] 2. The cefepime hydrochloride composition drug solution prepared in the first step is first ultrafiltered through a mem...

Embodiment 2

[0049] The cefamandole sodium combination medicine provided by the invention is made up of following medicinal composition weight ratio:

[0050] Cefepime Hydrochloride 2000

[0051] Lidocaine 200

[0052] Reduced Glutathione 120

[0053] Vitamin C 500

[0054] Cefepime hydrochloride may be replaced by cefepime hydrochloride, and the weight ratio is calculated by the weight of cefepime hydrochloride.

[0055] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0056] 1. Dissolve cefepime hydrochloride, lidocaine, reduced glutathione and vitamin C completely with water for injection of 50-200 times the weight of cefepime hydrochloride under normal speed stirring to prepare cefepime hydrochloride Oxime combination drug solution;

[0057] 2. The cefepime hydrochloride composition drug solution prepared in the first step is first ultrafilter...

Embodiment 3

[0074] The cefepime hydrochloride combined medicine provided by the invention is composed of the following medicinal ingredients in weight ratio:

[0075] Cefepime Hydrochloride 1550

[0076] Lidocaine 136

[0077] Reduced Glutathione 78

[0078] Vitamin C 345

[0079] Cefepime hydrochloride may be replaced by cefepime hydrochloride, and the weight ratio is calculated by the weight of cefepime hydrochloride.

[0080] The preparation process of the present invention: the process of the present invention is carried out under aseptic conditions at 18° C. to 20° C. according to the national GMP standard.

[0081] 1. Dissolve cefepime hydrochloride, lidocaine, reduced glutathione, and vitamin C with water for injection 50-200 times the weight of cefepime hydrochloride under normal speed stirring to obtain cefepime hydrochloride Oxime combination drug solution;

[0082] 2. The cefepime hydrochloride composition drug solution prepared in the first step is first ultrafiltered thr...

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Abstract

The invention discloses a cefepime hydrochloride combined medicament, which removes medicament heat and anaphylactic reaction of cefepime hydrochloride and adverse reactions thereof on liver damage, injection pain, phlebitis produced by injection and the like in the prior art. The cefepime hydrochloride combined medicament has the advantages of safe use, stable quality and reliable curative effect. A preparation process for the medicament is energy-saving, environmentally-friendly and pollution-free.

Description

technical field [0001] The invention relates to a cefepime hydrochloride combination drug and a preparation process thereof. Background technique [0002] Cefepime hydrochloride, other names are: cefepime, cefepime, cefepime, maspin, Lijiantai. A fourth-generation cephalosporin. The English name is Cefepime Hydrochloride, and the main ingredient is cefepime hydrochloride. It has broad antibacterial spectrum, strong antibacterial effect, rapid absorption after intravenous and intramuscular injection, and 100% absolute bioavailability. Cefepime hydrochloride is 85% not metabolized in the body. The existing cefepime hydrochloride injection is not stable when stored at room temperature, and there are drug allergies and adverse reactions to the gastrointestinal tract, liver, kidney, and blood system, as well as drug thermal reactions, intravenous infusion pain, and phlebitis. adverse reactions. Contents of the invention [0003] In order to overcome the defects in the prep...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K47/42A61K47/18A61K47/22A61P31/04
Inventor 邓学峰蔡海德
Owner 邓学峰
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