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Compound electrolyte medicine composition injection

A compound electrolyte and injection technology, applied in the field of medicine, can solve the problems of few varieties and incomplete specifications

Inactive Publication Date: 2010-10-06
胡建荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound electrolyte injections containing sodium lactate and sugar have been produced in China, such as MG3 and M3B, but there are not many varieties and specifications, and there is still a big gap

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 compound electrolyte injection

[0026] prescription:

[0027] Sodium chloride 5.26g

[0028] Sodium Gluconate 5.02g

[0029] Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 3.68g

[0030] Potassium chloride 0.37g

[0031] Magnesium Chloride (MgCl 2 ·6H 2 O) 0.3g

[0032] Water for injection 1000ml

[0033] making process

[0034] (1) Dissolve 5.02g sodium gluconate and 3.68g sodium acetate in water for injection with a total volume of 800ml, then add 5.26g sodium chloride, 0.37g potassium chloride and 0.3g magnesium chloride and mix and stir until completely dissolved;

[0035] (2) Add water for injection to 1000ml, adjust the pH to 7.4 with 0.1mol / L hydrochloric acid solution, heat the liquid to 80°C, then add 1g of charcoal for needles, stir and adsorb for 30min, and filter with a 0.45μm microporous membrane Decarburization, and fine filtration with a 0.3μm microporous membrane;

[0036] (4) bag...

Embodiment 2

[0038] The preparation of embodiment 2 compound electrolyte injection

[0039] prescription:

[0040] Sodium chloride 5.26g

[0041] Sodium Gluconate 5.02g

[0042] Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 3.68g

[0043] Potassium chloride 0.37g

[0044] Magnesium Chloride (MgCl 2 ·6H 2 O) 0.3g

[0045] Water for injection 1000ml

[0046] making process

[0047] (1) Dissolve 5.02g sodium gluconate and 3.68g sodium acetate in water for injection with a total volume of 800ml, then add 5.26g sodium chloride, 0.37g potassium chloride and 0.3g magnesium chloride and mix and stir until completely dissolved;

[0048] (2) Add water for injection to 1000ml, adjust the pH to 5.5 with 0.1mol / L hydrochloric acid solution, heat the liquid to 80°C, then add 5g of charcoal for needles, stir and adsorb for 30min, and filter with a 0.45μm microporous membrane Decarburization, and fine filtration with a 0.3μm microporous membrane;

[0049] (4) bagging and sealing;

[0050] (5) Ster...

Embodiment 3

[0051] The preparation of embodiment 3 compound electrolyte injection

[0052] prescription:

[0053] Sodium chloride 2.63g

[0054] Sodium Gluconate 2.51g

[0055] Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 1.84g

[0056] Potassium chloride 0.185g

[0057] Magnesium Chloride (MgCl 2 ·6H 2 O) 0.15g

[0058] Water for injection 500ml

[0059] making process

[0060] (1) Dissolve 2.51g sodium gluconate and 1.84g sodium acetate in water for injection with a total volume of 400ml, then add 2.63g sodium chloride, 0.185g potassium chloride and 0.15g magnesium chloride and mix and stir until completely dissolved;

[0061] (2) Add water for injection to 500ml, adjust the pH to 6.6 with 0.1mol / L phosphoric acid solution, heat the liquid to 80°C, then add 0.5g of charcoal for needles, stir and adsorb for 30min, and use a 0.45μm microporous filter membrane Decarburization by filtration, and fine filtration with a 0.3μm microporous membrane;

[...

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Abstract

The invention provides compound electrolyte medicine composition injection. The injection is mainly prepared from the following components in parts by weight: 5.26 parts of sodium chloride, 5.02 parts of sodium gluconate, 3.68 parts of sodium acetate (C2H3NaO2 .3H2O), 0.37 part of potassium chloride and 0.3 part of magnesium chloride (MgCl2 .6H2O).

Description

technical field [0001] The invention relates to a compound electrolyte pharmaceutical composition injection, which belongs to the technical field of medicine. Background technique [0002] Electrolyte and acid-base balance are necessary conditions for normal metabolism of human cells, and also necessary conditions for maintaining human life and the physiological functions of various organs. Electrolyte injection is mainly used clinically to correct water and electrolyte metabolism disorders in patients, maintain body fluid osmotic pressure and restore normal physiological functions of the human body. In recent years, the electrolyte injection has gradually transitioned from a single electrolyte to a compound electrolyte, and has been further developed into a lactated Ringer injection or a sugar-containing compound electrolyte injection of various concentrations, which provides convenience for clinical application. In Japan, the electrolyte injection is made into 4 kinds of ...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P3/12A61K31/19A61K31/191A61K33/00
Inventor 胡建荣
Owner 胡建荣
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