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Bio-particle three-dimensional manipulation device based on coil

A biological particle and manipulation device technology, applied in the field of special equipment in the field of life science and technology, can solve the problems of complex operation, biological particle pollution, unfavorable biological particle purity, etc., and achieve the effect of simple overall structure and easy control.

Inactive Publication Date: 2010-10-06
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] After searching the existing literature, it was found that Hakho L, Purdon A M, Westervelt, R M published a paper in IEEE Transactions on Magnetics (IEEE Magnetics Transactions), 2004, 40 (4): 2991-2993: Micromanipulation of biological systems with microelectromagnets ( micro-electromagnet micro-manipulation in biological systems) discloses a micro-manipulation technology of magnetic clamp biological particles, which requires the help of a third party, namely magnetic microspheres, that is, the combination of magnetic microspheres and biological particles, through the external magnetic field Controlling magnetic microspheres and then controlling biological particles, this technology is complex to operate, and is not conducive to the purity of biological particles, and it is easy to cause contamination of biological particles. Therefore, a new type of non-contact, non-third-party (magnetic microspheres) Particle micromanipulators have important theoretical and practical significance

Method used

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  • Bio-particle three-dimensional manipulation device based on coil
  • Bio-particle three-dimensional manipulation device based on coil
  • Bio-particle three-dimensional manipulation device based on coil

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Embodiment Construction

[0017] The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

[0018] Such as figure 1 , figure 2 with image 3 As shown, the present embodiment includes: biological particle 1, paramagnetic solution 2, chamber 3 and chip 4, wherein: the paramagnetic solution 2 is provided in the chamber 3, and the paramagnetic solution 2 is provided with biological particle 1, chip 4 and chip 4. The chamber 3 is bonded, and the chip 4 is photolithographically provided with a coil array 5 .

[0019] Such as Figure 4 As shown, considering the pin connection inside the coil, the coil array 5 needs to be fabricated by using multi-layer mask technology.

[0020] The paramagnetic solution 2 ...

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Abstract

The invention relates to a bio-particle three-dimensional manipulation device based on a coil in the technical field of life science. The device comprises a paramagnetism solution, a chamber and a chip, wherein the chamber is internally provided with the paramagnetism solution, the chip is bonded with the chamber and the chip is photo-etched with a coil array. By using a magnetic Archimedes effect and adopting a manipulation chip formed and assembled by an MEMS (Micro-Electro-Mechanical System) process, the invention has simple integral structure and easy manipulation, and can realize bio-particle micro-manipulation in a non-contact way without mechanical or photo damages under common magnetic field environment at normal temperature.

Description

technical field [0001] The invention relates to a special equipment in the technical field of life sciences, in particular to a coil-based three-dimensional manipulation device for biological particles. Background technique [0002] In the field of life sciences, the manipulation, capture, and movement of single or several biological particles without damage is the basis for the manipulation, processing, and testing of biological objects. Chromosome and cell analysis, protein and nucleic acid aggregation analysis, new species generation and other life science fields have great theoretical and practical significance. [0003] After searching the existing literature, it was found that Hakho L, Purdon A M, Westervelt, R M published a paper in IEEE Transactions on Magnetics (IEEE Magnetics Transactions), 2004, 40 (4): 2991-2993: Micromanipulation of biological systems with microelectromagnets ( micro-electromagnet micro-manipulation in biological systems) discloses a micro-mani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/42
CPCC12M33/00C12M35/04C12M35/02C12M35/06C12M23/20
Inventor 张卫平李世鹏陈文元刘武胡牧风
Owner SHANGHAI JIAO TONG UNIV
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