Preparation process of bone peptide soft capsule

Abstract

The invention discloses a preparation process of a bone peptide soft capsule, which is prepared by pressing and forming capsule contents on a soft capsule machine, wherein the capsule contents comprise the following raw materials in parts by weight: 5-30 parts of extract powder, 5-30 parts of chondroitin sulfate, 5-10 parts of protein calcium peptide, 1-8 parts of beewax and 20-50 parts of vegetable oil. The preparation process comprises the following steps: by using a principle that the beewax is subject to gradual temperature reduction below a melting point and is cured, slowly dispersing micro powder into mixed solution of the beewax and the vegetable oil to form powder-to-oil cream-shaped contents under highly stirring; and properly diluting the contents with the vegetable oil to forma cream with better flowability, wherein the cream is easily pressed into capsules. The invention has favorable stability and high dissolving speed, solves the problem of low content of high solid contents of the soft capsule contents prepared from water-soluble solid materials, ensures that the content of the water-soluble solid contents in the soft capsule contents is improved to over 50 percent by weight, improves the efficacy and reduces the administration dose. Meanwhile, no emulsifying agent is added, so that the natural attribute of products can be ensured.

Description

technical field [0001] The invention relates to a dosage form reform of an osteopeptide preparation, in particular to a preparation process of an osteopeptide soft capsule. Background technique [0002] At present, the biggest shortcoming of soft capsules is: prepare soft capsules with water-soluble solids as the main ingredient, because it is difficult to dissolve in oil, so the content of water-soluble solids in the soft capsule content is difficult to improve (usually controlled at 10-30 % (wt)), and a large amount of emulsifiers need to be added to prevent the water-soluble solids from settling and delaminating, which will affect the fluidity of the soft capsule content, and then affect the compression molding of the soft capsule. And the bone peptide soft capsule of the present invention is the extract powder that is made by the water extract of Chinese medicine Rhizoma Rhizoma Rhizoma Drynariae, Curcuma longa, Radix Glycyrrhizae through spray drying, mixes with chondro...

AI Technical Summary

Problems solved by technology

[0002] At present, the biggest shortcoming of soft capsules is: prepare soft capsules with water-soluble solids as the main ingredient, because it is difficult to dissolve in oil, so the content of water-soluble solids in the soft capsule content is difficult to improve (usually controlled at 10-30 % (wt)), and a large amount of emulsifier needs to be added to prevent the water-soluble solids from settling and delaminating, which will affect the fluidity of the soft capsule contents, thereby affecting the compression molding of the soft capsule

The extract powder and chondroitin sulfate prepared by its rhizoma drynariae, turmeric, licorice water extract are all water-soluble solid materials. If soft capsules are prepared according to the prior art, a large amount of emulsifiers such as Span , Tween is prepared into a suspension before pressing the soft capsule. In this way, the solid content in the content is low, which affects the efficacy of the product. At the same time, long-term use of a large amount of emulsifier added is not good for human health.