Brucea javanica oil enteric-coated microcapsule, preparation method and application thereof

Abstract

The invention belongs to the technical field of medicines and foods, relates to an enteric-coated microcapsule of an oily medicine or food, a preparation method and application thereof, in particular to the brucea javanica oil enteric-coated microcapsule, the preparation method and application thereof. The preparation method comprises the following steps: adding lecithin and an antioxidant to brucea javanica oil to absorb the oil to porous starch so as to obtain an oily soft material; adding an adhesive to the oily soft material, stirring at a high speed, granulating and then sieving to obtain a core material; and finally placing the core material in a bottom-spraying fluidized bed, and then spraying enteric-coated coating liquid to obtain the enteric-coated microcapsule. The brucea javanica oil enteric-coated microcapsule can conceal stench of the brucea javanica oil, avoid nausea and gastric stimulation, is easier to accept by patients, and has stability better than that of oral emulsion and more stable and regular drug release compared with single capsule; and the brucea javanica oil enteric-coated microcapsule and a further preparation thereof are applicable to treatment of various cancers such as lung cancer, brain metastasis, liver cancer and the like and adjunctive treatment after radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to the technical fields of medicine and food, and relates to an oily drug or food enteric-coated microcapsule and a preparation method and application thereof, in particular to a javanica javanica oil enteric-coated microcapsule and a preparation method and application thereof. Background technique [0002] Brucea javanica oil is an oily component extracted from the fruit of Brucea javanica, and the main component of the oil is oleic acid, which is one of the anti-tumor active ingredients. It is clinically used as an adjuvant therapeutic agent for the treatment of lung cancer, brain metastases of lung cancer, digestive tract tumors and liver cancer, with good curative effect. The current clinical application of Brucea javanica oil preparations is mainly provided in liquid form, such as the oil-in-water type Brucea javanica oil emulsion made from the petroleum ether extract of Brucea javanica as a raw material and refined soybean l...

AI Technical Summary

Problems solved by technology

In order to solve the unstable problem of emulsion storage, although dry emulsion and granule are developed, it is found that the granule and dry emulsion change color and the content of active ingredient oleic acid decreases under light, high temperature and high humidity conditions (Wu Fenglan, etc. .Research on the preparation and pharmacodynamics of Brucea javanica oil spray-dried emulsion, Chinese Journal of Pharmaceutical Sciences, 1999, 34 (2): 101-104), but also failed to effectively improve the stench and greasy feeling of oral preparations of Brucea javanica oil

Brucea javanica oil emulsion soft capsules and dripping pills have solved the problem of poor taste to a certain extent, but because gelatin is used as the capsule material, it is found that these two dosage forms are prone to rotten pills and disintegration over time during storage, and they are irritating to the stomach. There is no substantial improvement in the side effects of sexuality and greasy feeling

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