Brucea javanica oil enteric-coated microcapsule, preparation method and application thereof
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A technology of javanica javanica oil and javanica javanica, which is applied in the field of medicine and food, can solve the problems of no substantial improvement of greasy side effects, prone to rotten pills, gastric irritation, etc., to solve gastric irritation and poor taste, and reduce clinical symptoms. Side effects, easy to carry and store
Active Publication Date: 2010-11-03
SHENYANG PHARMA UNIVERSITY
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Abstract
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Problems solved by technology
In order to solve the unstable problem of emulsion storage, although dry emulsion and granule are developed, it is found that the granule and dry emulsion change color and the content of active ingredient oleic acid decreases under light, high temperature and high humidity conditions (Wu Fenglan, etc. .Research on the preparation and pharmacodynamics of Brucea javanica oil spray-dried emulsion, Chinese Journal of Pharmaceutical Sciences, 1999, 34 (2): 101-104), but also failed to effectivel
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Embodiment 1
[0029] Prescription 1
[0030] heart drug prescription
[0031] Brucea javanica oil 30g
[0032] Soy Lecithin 5g
[0033] Tert-butyl hydroquinone (TBHQ) 0.006g
[0034] Porous starch 60g
[0035] PVP-K90 2g
[0036] 95% ethanol 20ml
[0037] Enteric Coating Solution Prescription
[0038] Eudragit L 30D-55 30g (based on polymer dry weight)
[0039] Triethyl citrate 4.5g
[0040] Titanium dioxide 4.5g
[0041] Deionized water 20g
[0042]The first step is the preparation of the capsule core. Add the prescribed amount of soybean lecithin and antioxidant TBHQ into Brucea javanica oil, stir until dissolved, stand still, and filter. Add the filtered javanica javanica oil into the porous starch of the prescription amount, stir constantly to make the porous starch absorb the javanica javanica oil fully and evenly, and spray into the adhesive solution of the prescription amount to make the soft material, then stir and shear at high speed to make soft materials. The granules...
Embodiment 2
[0048] Prescription 2
[0049] heart drug prescription
[0050] Brucea javanica oil 30g
[0051] Lecithin 4g
[0052] Tert-butyl hydroquinone (TBHQ) 0.003g
[0053] Vitamin E 0.005
[0054] Porous starch 40g
[0055] 85% ethanol 8ml
[0056] Enteric Coating Solution Prescription
[0057] Eudragit L 30D-55 60g (based on polymer dry weight)
[0058] Triethyl citrate 15g
[0059] The specific operation steps and calculation are the same as in Example 1, and the coating efficiency is 98.1%.
Embodiment 3
[0061] Prescription 3
[0062] heart drug prescription
[0063] Brucea javanica oil 30g
[0064] Soy Lecithin 0.3g
[0065] Vitamin E 0.005
[0066] Porous starch 30g
[0067] PVP-K90 0.3g
[0068] 95% ethanol 5ml
[0069] Enteric Coating Solution Prescription
[0070] Dibutyl phthalate 30g (calculated by dry weight of polymer)
[0071] Talc powder 10g
[0072] 85% ethanol 500
[0073] The specific operation steps and calculation are the same as in Example 1, and the coating efficiency is 91.3%.
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Abstract
The invention belongs to the technical field of medicines and foods, relates to an enteric-coated microcapsule of an oily medicine or food, a preparation method and application thereof, in particular to the brucea javanica oil enteric-coated microcapsule, the preparation method and application thereof. The preparation method comprises the following steps: adding lecithin and an antioxidant to brucea javanica oil to absorb the oil to porous starch so as to obtain an oily soft material; adding an adhesive to the oily soft material, stirring at a high speed, granulating and then sieving to obtain a core material; and finally placing the core material in a bottom-spraying fluidized bed, and then spraying enteric-coated coating liquid to obtain the enteric-coated microcapsule. The brucea javanica oil enteric-coated microcapsule can conceal stench of the brucea javanica oil, avoid nausea and gastric stimulation, is easier to accept by patients, and has stability better than that of oral emulsion and more stable and regular drug release compared with single capsule; and the brucea javanica oil enteric-coated microcapsule and a further preparation thereof are applicable to treatment of various cancers such as lung cancer, brain metastasis, liver cancer and the like and adjunctive treatment after radiotherapy and chemotherapy.
Description
technical field [0001] The invention relates to the technical fields of medicine and food, and relates to an oily drug or food enteric-coated microcapsule and a preparation method and application thereof, in particular to a javanica javanica oil enteric-coated microcapsule and a preparation method and application thereof. Background technique [0002] Brucea javanica oil is an oily component extracted from the fruit of Brucea javanica, and the main component of the oil is oleic acid, which is one of the anti-tumor active ingredients. It is clinically used as an adjuvant therapeutic agent for the treatment of lung cancer, brain metastases of lung cancer, digestive tract tumors and liver cancer, with good curative effect. The current clinical application of Brucea javanica oil preparations is mainly provided in liquid form, such as the oil-in-water type Brucea javanica oil emulsion made from the petroleum ether extract of Brucea javanica as a raw material and refined soybean l...
Claims
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Application Information
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