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Total glycosides extractive of morinda plants, as well as preparation method and application thereof

A technology of Morinda officinalis and extract, which is applied in the field of total glycosides extract of Morinda officinalis

Inactive Publication Date: 2010-11-03
仇鑫 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no relevant literature records or research reports at home and abroad that use the total glycosides extract of Morinda officinalis in products for the treatment of sleep apnea syndrome (snoring)

Method used

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  • Total glycosides extractive of morinda plants, as well as preparation method and application thereof
  • Total glycosides extractive of morinda plants, as well as preparation method and application thereof
  • Total glycosides extractive of morinda plants, as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The preparation of embodiment 1 Morinda officinalis whole plant glycosides extract

[0039] Take 1000g of dried Morinda officinalis How plant whole herb, grind it to 10-100 mesh, and use 6 # Extract 10L of solvent oil and reflux extraction twice, each time for 2 hours, combine the extracts, concentrate under reduced pressure and recover solvent oil, the extract is mainly low polar components such as volatile oil, discard it; The dregs were extracted with 10L of 70% ethanol for 2 hours, extracted 3 times in total, combined the extracts, concentrated under reduced pressure to obtain 157g of ethanol extract; then dissolved the extract with 4 times the weight of 20% ethanol, and stood at 4°C After 12 hours, remove the pigmented layer (upper layer), concentrate the lower layer under reduced pressure until it has no ethanol smell, put it on a D-101 macroporous resin column, first elute with water to remove polysaccharides, proteins, etc., then elute with 50% ethanol, collect ...

Embodiment 2

[0040] Example 2 Preparation of Morinda Citrifolia Total Glycosides Extract

[0041] Take 1000g of the dried Morinda citrifolia (Morinda citrifolia L.) whole herb, crush it to 10-100 meshes, reflux extract with 5L of petroleum ether for 2 hours each time, combine the extracts, concentrate under reduced pressure to recover petroleum ether, The extract is mainly low-polar components such as volatile oil, which is discarded; the medicinal residue after the volatile oil is removed is extracted with 20L of 20% ethanol by heating and reflux, and the time is 2 hours. It is extracted 3 times in total, and the extracts are combined and concentrated under reduced pressure. Obtain 166g of ethanol extract; then dissolve the extract with 3 times the weight of 10% ethanol, leave it at 4°C for 12 hours, remove the pigment layer (upper layer), concentrate the lower layer under reduced pressure until there is no ethanol smell, and put it on HPD-500 macropore Resin column, first eluted with wat...

Embodiment 3

[0042] The preparation of embodiment 3 pseudo Morinda officinalis total glycosides extract

[0043] Take 1000g of dried Morinda shuhuaensis C.Y.Chen et M.S.Huang whole herb, crush it to 10-100 mesh, extract twice with 20L of acetone for 2 hours each time, combine the extracts, concentrate under reduced pressure to recover acetone , the extract is mainly low-polarity components such as volatile oil, which is discarded; the medicinal dregs after the volatile oil is removed are extracted with 5L of 95% ethanol by heating and reflux, and the time is 2 hours, and a total of 3 extractions are carried out. Concentrate to obtain 146g of ethanol extract; then dissolve the extract with 5 times the weight of 30% ethanol, let it stand at 4°C for 12 hours, remove the pigment layer (upper layer), and concentrate the lower layer under reduced pressure until it has no ethanol smell. Hole resin column, firstly eluted with water to remove polysaccharides, proteins, etc., then eluted with 20% et...

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Abstract

The invention discloses a total glycosides extractive of morinda plants, a preparation method thereof and application thereof in medicaments for treating snoring, and the weight percentage of total glycosides in the total glycosides extractive is 50-80 percent. The total glycosides extractive mainly contains the components of iridoids, such as monotropein, asperuloside and the like, morindone-6-O-beta-D-primeveroside) and the like. The preparation method comprises the following steps of: drying the morinda plants (comprising roots, stems, leaves and fruits), and crushing into 10-100meshes; carrying out reflux extraction by using petroleum ether or 6# extraction solvent oil or other organic solvents with polarity similar to that of the crushed morinda plant, and removing low-polarity components, such as essential oil and the like; heating the dregs of decoction with 20-95 percent alcohol for reflux extraction; condensing the extract, and dissolving with 10-30 percent alcohol; standing for 12 hours at 4 DEG C; removing pigment at the upper layer, carrying out vacuum condensing on the lower layer till alcohol has no odor, and processing the condensed liquid by using a macroporous resin column; washing with water to remove polysaccharide, protein and the like, eluting with 20-80 percent alcohol, and collecting the eluent; and condensing and drying to obtain the total glycosides extractive product of the morinda plants. The product of the invention is used for treating snoring (also called as Sleep apnea syndrome (SAS)), and has the advantages of quick and remarkable curative effect, no toxic or side effect, low price, convenient use and the like.

Description

technical field [0001] The invention relates to a total glycoside extract of Morinda officinalis, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Snoring, also known as sleep apnea syndrome (sleep apnea syndrome, SAS) in medicine, is a common and frequently-occurring disease that has only gradually attracted attention in recent years. During the period, multiple awakenings and awakenings lead to hypoxia, which is a relatively common sleep disorder in clinical practice. SAS is a state-dependent syndrome. Due to its predisposing factors such as obesity and narrow anatomical structure of the upper airway, it will cause state-dependent muscle tone reduction, resulting in repeated collapse of the upper airway. The disease spectrum is described It begins with simple snoring (pharyngeal vibrations), progresses to airflow limitation (hypopnea), and finally stops breathing completely (apne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/746A61P25/00A61P11/00C07H1/08A61K31/7048
Inventor 仇鑫
Owner 仇鑫
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