Anti-H3N8 subtype equine influenza virus monoclonal antibody and application thereof

A monoclonal antibody and influenza virus technology, applied in antiviral agents, antiviral immunoglobulins, antibodies, etc., can solve problems such as losses in horse breeding and horse racing industries
CN101892200AInactive Publication Date: 2010-11-24HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2010-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an anti-H3N8 subtype equine influenza virus monoclonal antibody and an application thereof. The anti-H3N8 subtype equine influenza virus monoclonal antibody is secreted by hybridoma cell strains with the microbial collection number of CGMCC No.3543. EL1SA, and Western-bolt methods prove that the monoclonal antibody of the invention has no cross reaction with equine infectious anemia virus, equine arteritis virus and normal chick embryo allantois fluid; and the abdominal dropsy ELISA valence of the H3N8 / 10 of the invention is 1:1.6*104. The anti-H3N8 subtype equine influenza virus monoclonal antibody of the invention can be applied to antigenicity analysis on A-type equine influenza virus, serodiagnosis, vaccine quality monitoring, epidemiological survey and other aspects.
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Description

technical field

[0001] The present invention relates to an equine influenza virus monoclonal antibody, in particular to an anti-H3N8 subtype equine influenza virus monoclonal antibody and a hybridoma cell strain secreting the monoclonal antibody. The use of the virus belongs to the field of equine influenza virus monoclonal antibodies. Background technique

[0002] Equine influenza (EI), referred to as equine influenza, is an acute fulminant infection of equine animals caused by equine influenza A virus (EIV) of the genus Influenzavirus of the family Orthomyxoviridae (Orthomyxoviridae). sick. Internationally, according to the difference of H and N of influenza virus, H is divided into 15 types, and N has 8 subtypes. There are only two subtypes that infect horses: vest I and vest II, which belong to the H7N7 and H3N8 subtypes, respectively.

[0003] Like other influenza viruses, equine influenza A virus spreads rapidly, often in an explosive fashion, which has brought cert...

Claims

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