Stable tegafur injection formula and preparation process thereof

A technology for tegafur and injection, which is applied in the field of stable tegafur injection formulation and preparation technology, can solve the problems of inconvenience to patients, decreased content of main drug, decreased pH value of finished products, etc., and achieves improved production capacity, increased safety Sexual protection, the effect of reducing the content of related substances
CN101897663AInactive Publication Date: 2010-12-01HARBIN PHARMA GROUP BIOLOGICAL ENG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HARBIN PHARMA GROUP BIOLOGICAL ENG
Publication Date
2010-12-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention researches a new preparation method aiming at the phenomena that the tegafur injection cannot realize scale production, has poor product stability and is easy to crystallize and the like so as to fulfill the purposes of producing the tegafur injection in scale, improving the product stability, removing crystals, reducing the content of related substance and the like. The pH value is adjusted by using carbonate and sodium hydroxide in a tegafur injection formula, the production speed is improved by heating in the preparation process, and the content of the related substances is reduced and the stability is improved by using active carbon.
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Description

technical field

[0001] The invention relates to a prescription of tegafur injection and a preparation process thereof, which are used by medical institutions for the treatment of tumor patients. Background technique

[0002] Tegafur injection is one of the effective new pyrimidine anti-cancer drugs in recent years, and it has inhibitory effect on most solid tumors. It is a derivative of fluorouracil, which is gradually converted into fluorouracil in vivo through liver activation and plays an anti-tumor role. It can interfere and block the synthesis of DNA, RNA and protein, and mainly acts on the S phase. It is a cell cycle-specific drug against pyrimidines. It is mainly used to treat gastrointestinal tumors, such as gastric cancer, rectal cancer, pancreatic cancer, liver cancer, and can also be used for breast cancer.

[0003] Compared with fluorouracil, tegafur injection has longer-lasting effect, better absorption and lower toxicity. The chemotherapy index is twice that...

Claims

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