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Plaque removing and fixing tablet for treating unstable carotid plaque

A carotid artery, stable technology, applied in the field of medicine, can solve the problem of plaque rupture drug side effects, etc., to achieve the effect of non-toxic side effects, lipid metabolism disorder elimination, and solve treatment problems

Inactive Publication Date: 2011-08-31
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a plaque-removing and solidifying patch for the treatment of unstable carotid plaques, which can effectively solve the problems of rupture of carotid plaques and large toxic and side effects of medication.

Method used

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  • Plaque removing and fixing tablet for treating unstable carotid plaque
  • Plaque removing and fixing tablet for treating unstable carotid plaque
  • Plaque removing and fixing tablet for treating unstable carotid plaque

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] In the specific implementation of the present invention, the speckle-removing and spot-fixing tablet is made of emblica emblica 27g, divine music 13g, hawthorn 27g, salvia miltiorrhiza 10g, lotus leaf 10g, moutan cortex 9g, alisma 13g and rhubarb 8g as raw materials. , mix emblica, lotus leaf and peony bark together, add 8 times the weight of emblica, lotus leaf and peony bark in water, soak for 2 hours, heat and distill and extract for 15 hours to obtain volatile oil, which is wrapped with β-cyclodextrin Combine, clathrate for later use, extract the boiled liquid after the volatile oil is concentrated until the relative density is 1.05 at 60°C, and then add ethanol with a mass concentration of 95% to make the alcohol content reach 60%, and refrigerate at 4°C for 20 hours. Suction filtration, recover ethanol, concentrate and dry the filtrate into a dry paste, set aside, then mix Divine Comedy, Hawthorn, Salvia, Alisma and Rhubarb together, add Divine Comedy, Hawthorn, Sa...

Embodiment 2

[0010] The patch-eliminating patch of the present invention can also be made of emblica 30g, divine music 15g, hawthorn 30g, salvia miltiorrhiza 12g, lotus leaf 12g, moutan cortex 10g, Alisma 15g, and rhubarb 9g. Mix it with Moutan Cortex, add 8 times the weight of Amlican emblica, lotus leaf and Moutan Cortex in water, soak for 2 hours, heat and distill and extract for 15 hours to obtain volatile oil, which is clathrated with β-cyclodextrin, and the clathrate is used for later use. The boiled liquid after extracting the volatile oil is concentrated until the relative density is 1.05 at 60°C, then add ethanol with a mass concentration of 95% to make the alcohol content reach 60%, refrigerate at 4°C for 24 hours, suction filter, recover ethanol, and filtrate Concentrate and dry into a dry paste, set aside, then mix Divine Comedy, Hawthorn, Salvia, Alisma and Rhubarb together, add 5 times the weight of Divine Comedy, Hawthorn, Salvia, Alisma, Rhubarb and 60% ethanol, soak for 2 h...

Embodiment 3

[0012] The present invention can also be made by emblica 33g, divine song 17g, hawthorn 33g, salvia miltiorrhiza 14g, lotus leaf 14g, moutan cortex 11g, Alisma 17g and rhubarb 10g as raw material drug, at first, emblica emblica, lotus leaf and moutan cortex are mixed in Together, add 8 times the weight of emblica, lotus leaf and peony cortex in water, soak for 2 hours, heat and distill and extract for 15 hours to obtain volatile oil, which is clathrated with β-cyclodextrin, and the clathrate is used for later use, and the water after extracting the volatile oil The boiling liquid is concentrated until the relative density is 1.05 at 60°C. Add ethanol with a mass concentration of 95% to make the alcohol content reach 60%. Refrigerate at 4°C for 22 hours, filter with suction, recover ethanol, concentrate and dry the filtrate into a dry paste, For later use, mix the Divine Comedy, Hawthorn, Salvia, Alisma, and Rhubarb together, add 5 times the weight of the Divine Comedy, Hawthorn...

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Abstract

The invention relates to a plaque removing and fixing tablet for treating an unstable carotid plaque, which solves the problems of breakage of the unstable carotid plaque and high toxic or side effect of a medicament. The technical scheme is that: the tablet is prepared from emblic leafflower fruit, medicated leaven, hawthorn, salvia miltiorrhiza bunge, lotus leaf, tree peony bark, oriental waterplantain rhizome and rhubarb serving as raw materials by the following steps of: mixing the emblic leafflower fruit, the lotus leaf and the tree peony bark; adding water for soaking; heating, distilling and extracting to obtain volatile oil; including the volatile oil with beta-cyclodextrin to obtain an inclusion compound for later use; concentrating decoction from which the volatile oil is extracted and adding ethanol into the concentrated decoction; refrigerating, leaching and recycling the ethanol; concentrating and drying filtrate into dry paste; mixing the medicated leaven, the hawthorn, the salvia miltiorrhiza bunge, the oriental waterplantain rhizome and the rhubarb; soaking the mixture with the ethanol; performing reflux extraction twice; combining the filtrate; filtering and recycling the ethanol; concentrating and drying the filtrate into dry paste; mixing and smashing the dry paste and the dry paste prepared from the emblic leafflower fruit, the lotus leaf and the tree peonybark; uniformly mixing the paste and the inclusion compound; sieving the mixture through a 60-mesh sieve; and tableting the sieved mixture. The tablet has good plaque removing and fixing effect and does not have toxic or side effect if taken for a long time.

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to a plaque-removing plaque-fixing patch for treating unstable plaques of carotid arteries. 2. Background technology [0002] The rupture of carotid artery unstable plaque (also known as cervical AS plaque) is the main cause of cerebrovascular disease. For plaques rich in lipids and inflammatory cells, the plaque fibrous cap becomes thinner due to the fluidity of lipids. The accumulation or rupture of inflammatory cells in the plaque shoulder causes plaque rupture, and the unstable plaque rupture in the carotid artery is mainly composed of atheroma core and atheroma formed by the mixture of lipids (mainly low-density lipoprotein) and necrotic cells and their residual substances. Composed of fibrous cap, due to the continuous deposition of lipids, the plaque under the arterial intima gradually increases, due to the fluidity of lipids, the fibrous cap of the plaque becomes thinner, resultin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K9/20A61P3/06
Inventor 张金生王景辉何庆勇张宝霞王小雅赵珍珍安秀丽
Owner HENAN UNIV OF CHINESE MEDICINE