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Labisia pumila extracts for reducing the risk of cardiovascular diseases

An extract, cardiovascular technology, applied in the field of application of Labisia Pumila extract to reduce the risk of cardiovascular disease

Inactive Publication Date: 2010-12-29
马来西亚政府
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cultivating Labisia pumila is now available, this herbaceous shrub grows wild only on the forest floor in Peninsular Malaysia and Kalimantan

Method used

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  • Labisia pumila extracts for reducing the risk of cardiovascular diseases
  • Labisia pumila extracts for reducing the risk of cardiovascular diseases
  • Labisia pumila extracts for reducing the risk of cardiovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the first embodiment, the effect of the extract on adipokinin, glucose utilization rate, body weight and uterine soundness in mice was studied.

[0025] Hysterectomized Sprague-Dawley mice received daily doses of 10 to 50 mg of a standardized liquid extract of Labisia pumila per kilogram of body weight for thirty days. The extract was first dissolved in two to three milliliters of distilled water, and the solution was gavaged to mice. At the end of the study, glucose levels were measured in blood collected from the tail veins of the mice. The animals were then sacrificed, their adipose tissue, skeletal muscle, and liver tissue were excised, and gene expression studies were performed immediately. Plasma was stored at minus eighty degrees until analysis. After recording the weight of the uterus, a histological examination of the uterus is then performed. Measure the levels of insulin and adiponin hormones in plasma samples using enzyme or radioimmunoassay kits.

[...

Embodiment 2

[0033] In another embodiment, a double-blind placebo-controlled study was conducted with 116 healthy female voluntary participants ranging in age from 48 to 55 years. Participants received 140 mg, 280 mg or 560 mg of the extract or a placebo per day for 360 days. Lipid profiles were generally improved, with statistically significant effects on triglycerides (p=0.003) and apolipoprotein B (p=0.006) (see Table 1).

[0034] experiment

placebo

(n=32)

140mg /

Day (n=29)

280mg / day

(n=32)

560mg /

Day (n=25)

P value

total cholesterol

(Millimoles /

Lift)

5.4

5.5

5.0

5.0

0.077

Triglycerides

(Millimoles /

Lift)

2.02

1.24

1.30

1.16

0.003

HDL

white cholesterol

(Millimoles /

Lift)

1.14

1.11

1.09

1.01

0.517

LDL

white cholesterol

(Millimoles /

Lift)

3.55

3.73

3....

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Abstract

There is disclosed a standardised aqueous extract of Labisia pumila, as a herbal medicine or as a botanical drug, that can reduce the risk or progression of cardiovascular diseases. This extract addresses factors that influence pathophysiological changes associated with insulin resistance, obesity, metabolic syndrome, diabetes and aging.

Description

technical field [0001] The present invention relates to the use of a standardized liquid extract of Labisia Pumila leaves prepared by the method disclosed in Malaysian Patent Application No. PI 20054784 as a herbal or botanical drug, especially for diseases affecting pathophysiology Changing factors (including the regulation of different related genes), especially in women, related to insulin resistance, obesity, metabolic syndrome, diabetes and aging, thereby reducing the risk of cardiovascular disease or slowing its progression . Background technique [0002] Due to rapid urbanization and changing lifestyles, cardiovascular disease is now the leading cause of death in all countries. Many factors have been found to have varying degrees of influence on the individual's risk of cardiovascular disease, including age, sex, genetics, and lifestyle, especially dietary habits. [0003] Although healthy living habits, such as exercise and a balanced diet, are the best and most ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61P9/00
CPCA61K36/185A61P15/00A61P3/00A61P3/04A61P43/00A61P9/00A61P9/10A61P3/10
Inventor 温·那撒蒙·温·穆罕默德
Owner 马来西亚政府