Quickly wetting material containing hydrocolloid, method for its production and also use thereof
A fast, gelatin-based technology for applications, prosthetics, food preparation, etc., which can solve problems such as high cost and reduced simplicity
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Embodiment 1
[0071] Example 1 : Manufacture of quick-wetting gelatin sponge
[0072] This example describes the application of the method of the invention for the manufacture of a rapidly wettable material containing hydrocolloids in the form of a gelatin sponge.
[0073] A commercially available gelatin sponge used as a wound dressing was used as starting material. As a result of gelatin cross-linking, these sponges are insoluble in water, but degradable under physiological conditions.
[0074] In a first step, a gelatin sponge of original dimensions 80×50×10 mm was rolled to a thickness of 4 mm, thus obtaining dimensions of 80×50×4 mm. As a result of this compression of the gelatin sponge by 60% in one direction, the cellular structure is partially broken, allowing the subsequent plasma treatment to have the highest possible efficiency on the entire inner surface of the sponge.
[0075] The sponge is then dried under vacuum (<1 mbar) for 2 hours at 50° C. to reduce the water content ...
Embodiment 2
[0081] Example 2 : Determination of initial wettability
[0082] To quantitatively determine the wettability of plasma-treated gelatin sponges according to the invention, the time required for a dry sponge to absorb a specific amount of aqueous solution (initial wettability) was measured.
[0083] The steps of the method are schematically shown in figure 1 middle. In each case, 50 μl of PBS buffer (10) containing 0.03% by weight of methylene blue was placed on a spot on the surface of the sponge (14) using a pipette (12). The length of time from placing the droplet (t=0) to its complete penetration into the sponge (t=x) was measured. The endpoint was determined visually by identifying the sponge structure under the penetrating droplet (16).
[0084]At least three gelatin sponges were tested separately and measurements were made at 4 to 6 points on the surface of each sponge. An average value is formed from all these measurements.
[0085] For the gelatin sponge produced...
Embodiment 3
[0089] Example 3 : Determination of blood absorption capacity
[0090] In this example, the blood-absorbing capacity of a gelatin sponge according to the invention (produced according to Example 1) was quantitatively determined and compared with the starting product not treated with plasma.
[0091] To this end, dry sponges were individually weighed and then placed on the surface of a blood sample (human blood with a hematocrit of about 50%) for 10 seconds. The sponge was then placed on the filter paper for 60 seconds to allow excess blood to flow out. The sponge with absorbed blood was weighed again and the amount of blood absorbed relative to the weight of the sponge material was calculated from the difference from the original weight. Mean values were correspondingly formed from three measurements.
[0092] A stark difference between the two sponges was also evident in this experiment: the plasma-treated gelatin sponge absorbed about 58 times its own weight in blood, ...
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Abstract
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