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Method for preparing Gentongping tablets

A flat tablet and prescription technology, applied to medical preparations containing active ingredients, pharmaceutical formulas, non-central analgesics, etc., can solve the problem that Gentongping extract is not easy to dry and crush, and Gentongping extract particles are easy to absorb Problems such as moisture deterioration, high labor intensity, etc., to improve drug safety, solve gastric irritation, and improve product quality

Active Publication Date: 2011-04-13
上海复旦复华药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of this invention is to provide a new method for preparing Gentongping Tablets, to overcome the above-mentioned defects in the prior art, to solve the problem that Gentongping extract is not easy to dry and pulverize, the process is complicated, the labor intensity is large and Gentongping extract Ointment granules are easy to absorb moisture and deteriorate, and have a stimulating effect on the stomach, and are prone to technical problems such as unstable tablet weight, loose tablets, and splits, so as to improve the product qualification rate of Gentong Tablets and reduce preparation costs to meet the needs of industrial production

Method used

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  • Method for preparing Gentongping tablets
  • Method for preparing Gentongping tablets
  • Method for preparing Gentongping tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] a) Preparation of Gentong Pingqing Ointment

[0027] Weigh according to the prescription: 80g Shenjincao, 80g Gouji (sanded to remove hair), 80g Dipsacus, 53g Rehmannia glutinosa, 53g safflower, 53g frankincense (roasted with vinegar), 53g myrrh (roasted with vinegar), 53g peach kernel, Knee 53g, Radix Puerariae 53g, Radix Glycyrrhizae 26.5g Eleven herbs and 45g Paeoniae Alba, add water and decoct twice, the first time is 1.5 hours, the second time is 1 hour; Combine the filtrate, filter, and the filtrate is concentrated under reduced pressure to relative density ( 50 ℃) is 1.1 ~ 1.2 Qing Gao, that is, Gentong Ping Qing Gao.

[0028] b) Preparation of Gentongping dry extract particles

[0029] Get 168g Radix Paeoniae Alba, be ground into 80 mesh fine powders, place in the multi-functional pill-making coating machine;

[0030] Turn on the multi-functional pill-making coating machine, heat Gentong Pingqing Paste to 55-65°C, use it as a binder, and spray it into the mult...

Embodiment 2

[0059] The difference between the present embodiment and Example 1 is only that: the preparation of Gentongping dry extract coating granule is to adopt 11g shellac, add the ethanol aqueous solution that volume fraction is 95% and be mixed with the shellac that mass fraction is 35% Ethanol solution was used as coating solution. The rest of the content is the same as described in Example 1.

[0060] The test data of moisture, content, bulk density, angle of repose, moisture absorption rate, and dissolution of the coated granules of Gentongping dry extract obtained in this example are shown in Table 1.

Embodiment 3

[0062] The only difference between this example and Example 1 is that the coated granules of Gentongping dry extract are prepared by using 11 g of enteric-coated Opadry and adding an aqueous ethanol solution with a volume fraction of 88% to prepare a mass fraction of 25%. The enteric Opadry ethanol solution was used as the coating solution. The rest of the content is the same as described in Example 1.

[0063] The test data of moisture, content, bulk density, angle of repose, moisture absorption rate, and dissolution of the coated granules of Gentongping dry extract obtained in this example are shown in Table 1.

[0064] Table 1 Performance testing data of Gentongping dry extract coated granules in Examples 1-3

[0065]

[0066] As can be seen from Table 1: adopt shellac, hydroxypropyl methylcellulose phthalate (hypromellose peptidate, HPMCP) or enteric-coated Opadry as the coating material of Gentongping dry extract particles, Both can effectively solve the problem that...

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Abstract

The invention discloses a method for preparing Gentongping tablets. The method comprises the following steps of: preparing Gentongping extract; preparing Gentongping extract particles by fluidized bed one-step granulation technology; coating the Gentongping extract particles by powder coating technology to prepare coated Gentongping extract particles; preparing Gentongping tablet cores by direct compression technology; and finally coating with thin films to prepare the Gentongping tablets. The preparation method solves the problems of dry extract, difficulty of crushing, high labor intensity, serious dust pollution, difficulty of process control during wet granulation, high probability of moisture absorption and deterioration of particles, poor fluidity, high probability of cracking and breaking, large tablet weight difference, poor hardness and the like existing in the preparation process of the conventional Gentongping tablets, overcomes the defect of stimulation to the stomach by the conventional Gentongping tablets, improves the medication safety, has the advantages of reliable process, stable quality, low labor intensity and the like, is easy to operate and is suitable for requirements of industrial production.

Description

technical field [0001] The invention relates to a preparation method of Gentongping Tablets, in particular to a new method for preparing Gentongping Tablets, a traditional Chinese medicine extract tablet, and belongs to the technical field of preparation of pharmaceutical preparations. Background technique [0002] Cervical spondylosis, also known as cervical spondylosis, belongs to the category of arthralgia, flaccidity, and Jue syndrome in traditional Chinese medicine. It is a disease caused by chronic muscle strain and wind-cold-damp pathogenic invasion of the human body, resulting in degeneration of cervical bone joints or soft tissues inside and outside the cervical spinal canal. The disease is common and multiple, and there is no specific treatment. In the 1970s, Professor Yang Keqin of Beijing Medical University, the leading orthopedic doctor in my country, developed a good medicine for cervical spondylosis - "Gentongping Tablet" based on the theory of promoting blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/36A61P19/08A61P29/00
Inventor 任昉
Owner 上海复旦复华药业有限公司
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