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Method for separating capsaicinoids from chilli extract

A technology of total alkaloids of capsicum and capsicum essence, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant/algae/fungus/moss components, etc., and can solve problems such as high toxicity of organic solvents, complex processes, and serious environmental pollution , to achieve the effect of no pollution to the environment, high product purity and simple process

Inactive Publication Date: 2011-04-13
HUNAN AGRICULTURAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional extraction method of capsaicin generally uses organic solvents to extract from capsicum, which is complicated in process and serious in environmental pollution
In recent years, microwave extraction, supercritical fluid extraction, molecular distillation, functional resin separation, etc. have also been applied to the extraction and separation of capsaicin, but the existing methods require a large investment in equipment, complex processes, high toxicity of organic solvents, and serious environmental pollution. Production high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0008] Take capsicum extract 10g, dissolve and extract with 2L of 30% ethanol, and then dynamically adsorb with 75mL D101 macroporous resin. First use 30% ethanol 300mL to elute and remove impurities from the macroporous resin column that has absorbed capsaicinoid substances, then use 70% ethanol 300mL to elute capsaicinoid substances, collect the eluate, and recover the solvent under reduced pressure to obtain Ointment. Through HPLC analysis, the total alkaloid content of capsicum was 82.7%, and the yield was 81.3%.

Embodiment approach 2

[0010] Take capsicum extract 10g, dissolve and extract with 2L of 40% ethanol, and then dynamically adsorb with 80mL HPD-200 macroporous resin. First use 300mL of 40% ethanol to elute and remove impurities from the macroporous resin column adsorbed with capsaicinoids, then elute capsaicinoids with 300mL of 70% ethanol, collect the eluate, and recover the solvent under reduced pressure to obtain The oil paste, analyzed by HPLC, shows that the total alkaloid content of capsicum is 83.6%, and the yield is 80.5%.

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PUM

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Abstract

The invention discloses a method for separating capsaicinoids from chilli extract. The method comprises the following steps: utilizing lower alcohol to extract the chilli extract which is utilized as a raw material; utilizing D101 resin and other nonpolar macroporous absorption resins to dynamically absorb the lower alcohol solution; then utilizing dilute ethanol to carry out elution and impurityremoval on the macroporous absorption resins absorbed with capsaicine substances; and finally utilizing 60-90% ethanol to carry out elution and enrichment on the capsaicine substances, reducing pressure and recovering a solvent, thus obtaining ointment with the capsaicinoids content of more than 80% and the yield of more than 80%. By utilizing the method disclosed by the invention to separate thecapsaicinoids from the chilli extract, the process is simple, the product purity is high, and no environmental pollution is caused.

Description

technical field [0001] The invention relates to a method for separating total alkaloids of capsicum from capsicum essence. Background technique [0002] Capsicum extract is a by-product of producing capsanthin, and the active ingredient in capsicum extract is capsaicin. The traditional extraction method of capsaicin generally uses organic solvents to extract from capsicum, which is complex in process and serious in environmental pollution. In recent years, microwave extraction, supercritical fluid extraction, molecular distillation, functional resin separation, etc. have also been applied to the extraction and separation of capsaicin, but the existing methods require a large investment in equipment, complex processes, high toxicity of organic solvents, and serious environmental pollution. Production high cost. Contents of the invention [0003] The object of the present invention is to disclose a method for separating total alkaloids of capsicum from capsicum essence wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81
Inventor 董新荣杨华
Owner HUNAN AGRICULTURAL UNIV
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