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Method for preparing enteric capsules by taking leech as raw material

A technology of enteric-coated capsules and leeches, applied in medical raw materials derived from leeches/worms, capsule delivery, and resistance to vector-borne diseases, etc., can solve the problems of leech activity reduction, crushing, low-temperature drying and sterilization without any research

Active Publication Date: 2012-02-29
CHONGQING DUOPUTAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patent application No. 96102147.0 discloses that the whole medicine of leeches can be prepared into pharmaceutical preparations by methods such as freezing leeches, crushing, and low-temperature drying. Although this method can use the whole medicine of leeches as medicine, there is no research on pulverization, low-temperature drying and sterilization.
In the prior art, there is also a freeze-drying method to dry the leeches, but in this method, in the process of crushing the dry matter, a large amount of heat is generated during mechanical shearing, thereby reducing the overall activity of the leeches

Method used

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  • Method for preparing enteric capsules by taking leech as raw material
  • Method for preparing enteric capsules by taking leech as raw material
  • Method for preparing enteric capsules by taking leech as raw material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Get fresh and alive leeches, add water to wash, freeze, the freezing temperature is minus 5 ℃, and the number of days of freezing is 15 days. The frozen leeches are mashed with a tissue masher. Add pharmaceutical excipients lactose, microcrystalline cellulose, compressible starch and mix evenly, vacuum dry at 30°C, pulverize, and use C O 60 Sterilized by radiation, filled into enteric-coated capsules, obtained.

Embodiment 2

[0068] Get fresh and alive leeches, add water to wash, freeze, the freezing temperature is minus 10 ℃, and the number of days of freezing is 12 days. The frozen leeches are mashed with a tissue masher, and the speed of the masher is 5000 rpm. substance) add pharmaceutical excipients mannitol, sorbitol, xylitol and mix evenly, vacuum dry at 50°C, pulverize, and use C O 60 Sterilized by radiation, filled into enteric-coated capsules, obtained.

Embodiment 3

[0070] Get fresh and alive leeches, add water to wash, freeze, the freezing temperature is minus 5 ℃, and the number of days of freezing is 15 days. The frozen leeches are mashed with a tissue masher, and the masher speed is 3000 rpm. Add pharmaceutical excipients starch, lactose, xylitol and mix evenly, vacuum dry at 50°C, pulverize, and use C O 60 Sterilized by radiation, filled into enteric-coated capsules, obtained.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a method for preparing enteric capsules by taking leech as a raw material. A novel process method is selected preferably by study on freezing temperature, number of freezing days, a crushing process, a low-temperature drying process and a sterilizing process to research and by taking antithrombin activityas an index. The process method organically combines different process parameters, namely, the process method avoids high mechanical force and high temperature as much as possible to achieve the effect of keeping the activity of the leech. The enteric capsules in which the fresh leech is used as a medicament wholly and which is prepared by using the process method have higher antithrombin activity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of enteric-coated capsules with leeches as raw materials. Background technique [0002] Leeches, commonly known as leeches, grow and reproduce in inland freshwater waters. They are traditional special medicinal aquatic animals in my country. Modern pharmacological studies have shown that leeches have pharmacological effects such as: [0003] 1. The effect on blood. Hirudin can prevent the effect of thrombin on fibrin and hinder blood coagulation. Hirudin can still secrete a histamine-like substance, which can expand capillaries. Hirudin alcohol extract has a better effect on inhibiting blood coagulation. Peach kernel is the strongest, and the effect of hirudin preparation is stronger than that of water preparation. Hirudin 20mg can prevent the coagulation of 100g human blood. Leech water extract has obvious inhibitory effect ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/62A61K9/48A61P7/02A61P9/10A61P15/04A61P15/06A61P35/00
CPCY02A50/30
Inventor 甘奇志曾新
Owner CHONGQING DUOPUTAI PHARMA