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Syringin pharmaceutical composition and preparation method and application thereof

A technology of syringin and composition, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of no syringin injection, and achieve safe and reliable clinical use, ensure stability and quality, and reduce impurities Effect

Inactive Publication Date: 2011-05-04
王洪涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the existing injections containing syringin only have Acanthopanax injection and other traditional Chinese medicine compound preparations, and there is no syringin injection for clinical use.

Method used

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  • Syringin pharmaceutical composition and preparation method and application thereof
  • Syringin pharmaceutical composition and preparation method and application thereof
  • Syringin pharmaceutical composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation process of the syringin pharmaceutical composition is as follows: take 4.0 g of syringin and dissolve it in 200 ml of propylene glycol, heat it to 50-60 ° C until it is completely dissolved, adjust the pH value to 7.5 with an appropriate amount of dilute sodium hydroxide solution, and make up water for injection To 2000ml and pass through a 0.22μm membrane to make 1000 tubes, fill with nitrogen, fill in ampoules, and sterilize.

Embodiment 2

[0037] For the syringin pharmaceutical composition described in Example 1, take 10.0 g of syringin and dissolve it in 400 ml of propylene glycol, heat it to 50-60 ° C until it is completely dissolved, adjust the pH value to 7.0 with an appropriate amount of dilute sodium hydroxide solution, and make up for the injection Water to 2000ml and pass through a 0.22μm membrane to make 1000 tubes, fill with nitrogen, fill in ampoules, and sterilize.

Embodiment 3

[0039] For the syringin pharmaceutical composition described in Example 1, take 20.0 g of syringin and dissolve it in 800 ml of propylene glycol, heat it to 50-60 ° C until it is completely dissolved, adjust the pH value to 7.0 with an appropriate amount of dilute sodium hydroxide solution, and make up for injection Water to 2000ml and pass through a 0.22μm membrane to make 1000 tubes, fill with nitrogen, fill in ampoules, and sterilize.

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Abstract

A syringin pharmaceutical composition and preparation method and application thereof. Only acanthopanax injection and other Chinese herbal medicine compound preparations are related with the syringin containing injections on the market, and no syringin injection is available for clinical use. The syringin pharmaceutical composition comprises syringin with a purity of above 98%, a pharmacologically allowable pH adjusting substance, a cosolvent, and the balance of water, wherein the concentration of the syringin is 2mg / ml-250mg / ml and the concentration of the cosolvent in the composition is 0.1ml / ml-0.65ml / ml, and the pH adjusting substance, by weight, is added in an amount sufficient to adjust the pH in a range of 3.5-7.5. The invention provides a clinically safe injection with pharmacological effects of fatigue prevention, tranquilization, vessel dilation, and hemostasis.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition with pharmacological effects such as anti-fatigue, calming the nerves, dilating blood vessels, reducing blood viscosity, and stopping bleeding, in particular to syringin injection and a preparation method thereof. Background technique: [0002] At present, the existing injections containing syringin only have Acanthopanax injection and other traditional Chinese medicine compound preparations, and there is no syringin injection for clinical use. Syringin is the substance isolated and extracted from the bark of Oleaceae Syringa vulgaris L., Araliaceae Acanthopanax and other plants. It is the main active ingredient in Chinese medicinal materials such as Acanthopanax. Molecular formula: C 17 h 24 o 9 , molecular weight: 372.36, has a clear chemical structure: [0003] Invention content: [0004] The purpose of the present invention is to provide a syringin composition that can be safely used cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/08A61P25/20A61P9/08A61P7/04A61P1/16A61P43/00
Inventor 王洪涛
Owner 王洪涛
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