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Callicarpa nudiflora effective part with hemostatic effect and pharmaceutical preparation thereof

A technology of Auranthus nudiflora and its effective parts, which is applied in the field of preparation of effective parts of Aurantia nudiflora and its pharmaceutical preparations

Inactive Publication Date: 2011-05-11
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Auranthus nudica is rich in flavonoids, so far, there is no report on the effective part with hemostatic effect isolated from Aurantia nudica

Method used

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  • Callicarpa nudiflora effective part with hemostatic effect and pharmaceutical preparation thereof
  • Callicarpa nudiflora effective part with hemostatic effect and pharmaceutical preparation thereof
  • Callicarpa nudiflora effective part with hemostatic effect and pharmaceutical preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take the naked flower purple pearl and add water to decoct twice, each time for 1.5 hours, and the water consumption is 8 times the amount (L / kg). Combine the decoctions, filter, concentrate the filtrate to a clear paste at 1.20 (50°C), add ethanol to make the alcohol content to 70%, recover the ethanol, add water to make a solution containing 1g of crude drug per mL, extract with ethyl acetate, and recover the solvent , and the residue was dried to obtain the extract of the effective fraction of the flavonoids of Auranthus nudica.

Embodiment 2

[0049] Add water to decoct the naked flower purple pearl twice, each time for 2 hours, and the water consumption is 12 times the amount (L / kg). Combine the decoctions, filter, concentrate the filtrate to a clear paste of 1.10 (60°C), add ethanol to make the alcohol content 65%, reclaim the ethanol, and the solution concentration is 1:8 (crude drug amount g: dispersion volume mL), polyamide column The diameter-to-height ratio is 1:7, and the loading volume is 100-500 mg / mL (based on the amount of crude drug). First, 4 times the column volume is eluted with water, and then 5 times the column volume is eluted with 50% ethanol, and the eluate is collected. , recover the solvent, and dry the residue to obtain the effective part extract of the flavonoids of the pachyderm.

Embodiment 3

[0051] Take 1 part of the extract of the effective part of Aurora nudiflora and 2 parts of starch, mix them, granulate with 95% ethanol, dry, granulate, and pack into capsules to obtain capsules.

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Abstract

The invention discloses a callicarpa nudiflora effective part extract with a hemostatic effect and a preparation method of a pharmaceutical preparation of the callicarpa nudiflora effective part extract. The effective part extract and the pharmaceutical preparation contain total flavonoids of the callicarpa nudiflora and are extracted and separated from the callicarpa nudiflora which is a traditional Chinese medicine plant, the content of the total flavonoids is not less than 50%, and the effective part extract and the pharmaceutical preparation mainly contain galuteolin, luteolin-3'-O-beta-D-glucopyranoside, luteolin-4'-O-beta-D-glucopyranoside, calliterpenone, luteolin, apigenin and cosmosiin. The effective part extract and the pharmaceutical preparation have significant hemostatic effects.

Description

technical field [0001] The present invention relates to a kind of active part of Nudiflora Hook.ex Am. which has remarkable hemostatic effect and the preparation method of the pharmaceutical preparation thereof. The active part of the total flavonoids and the preparation method of the preparation thereof. Background technique [0002] Callicarpa nudiflora Hook.ex Am. is a plant of the genus Callicarpa nudiflora Hook.ex Am. It is distributed in Hainan, Guangdong, Guangxi and other places in my country. Foreign countries are mainly distributed in India, Vietnam and Malaysia. Its roots, stems, and leaves can be used as medicine. It has the functions of antibacterial and hemostasis, anti-inflammatory and detoxification, dispersing stasis and swelling, and dispelling wind and dampness. External use to treat burns, scalds and traumatic bleeding. P. nudiflora is rich in flavonoids. Up to now, it has not been reported to isolate the effective part with hemostatic effect from P. n...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P7/04
Inventor 朱才庆胡蓉李玉云姚闽张俊明郑国安吴迪曾宪仪李忠贵余华赖娟华陈新菊
Owner 江西省药物研究所
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