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Drug carrier of apigenin and preparation method

A kind of technology of apigenin and medicine, applied in the field of drug carrier and preparation of apigenin, can solve the problems of high phase transition temperature and unfavorable application of sucrose ester, achieve high antioxidant activity, increase antioxidant activity, and increase solubility

Active Publication Date: 2018-02-06
海生健康科技(青岛)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has attracted much attention because of its antitumor and antibacterial biological activities, but the high phase transition temperature of sucrose esters is not conducive to its application in the pharmaceutical field

Method used

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  • Drug carrier of apigenin and preparation method
  • Drug carrier of apigenin and preparation method
  • Drug carrier of apigenin and preparation method

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Experimental program
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Effect test

preparation example Construction

[0043] Phase Diagram Preparation

[0044] First, a certain mass ratio of surfactant S1570 / NaDC is placed in a stoppered colorimetric tube, and isopropanol is added in a mass ratio of 6:4 between surfactant and co-surfactant isopropanol to form a mixed Surfactant system (EM). Secondly, according to the mass ratio of the mixed surfactant and oil from 10:0 to 0:10, the oil phase was weighed successively in different colorimetric tubes, and stirred and mixed with a vortex mixer. Mix well, then stir and dissolve at 50-60°C. Add double-distilled water dropwise to the colorimetric tube at intervals of 2%, and finally observe it in a constant temperature water bath at 40°C, and determine the microemulsion phase region by the clear, transparent and flowable appearance.

[0045] The phase behavior of the S1570 / NaDC / isopropanol / isoamyl acetate / 5% NaCl aqueous solution system was studied at 40°C by introducing different contents of NaDC. The pseudo-ternary phase diagram is shown in figu...

Embodiment 1

[0055] Place 2.295g sucrose stearate, 0.405g sodium deoxycholate, 1.8g isopropanol and 0.5g isoamyl acetate in a stoppered colorimetric tube, mix it evenly with a vortex mixer, and set it at 50- Fully stir in a constant temperature water bath at 60°C to dissolve it. Then, 5g of 5% NaCl aqueous solution was added dropwise to the colorimetric tube, placed in a water bath, stirred and mixed, and finally left to stand in a constant temperature water bath at 40°C to achieve phase equilibrium, and the obtained microemulsion was the drug-loaded microemulsion. Emulsion, denoted as P 1 .

Embodiment 2

[0057] Place 2.16g sucrose stearate, 0.54g sodium deoxycholate, 1.8g isopropanol and 0.5g isoamyl acetate in a stoppered colorimetric tube, mix it evenly with a vortex mixer, and set it at 50- Fully stir in a constant temperature water bath at 60°C to dissolve it. Then, 5g of 5% NaCl aqueous solution was added dropwise to the colorimetric tube, placed in a water bath, stirred and mixed, and finally left to stand in a constant temperature water bath at 40°C to achieve phase equilibrium, and the obtained microemulsion was the drug-loaded microemulsion. Emulsion, denoted as P 2 .

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Abstract

The invention discloses a drug carrier of apigenin and a preparation method. The drug carrier is micro-emulsion prepared by mixing sodium deoxycholate, sucrose stearate, isopropyl alcohol, ethyl acetate and a sodium chloride water solution. The drug carrier disclosed by the invention takes the ethyl acetate as an oil phase and the apigenin has highest anti-oxidization activity and maximum accumulative releasing rate.

Description

technical field [0001] The invention relates to a drug carrier of apigenin and a preparation method thereof. Background technique [0002] As a natural flavonoid compound, apigenin is widely distributed in a variety of vegetables and medicinal plants, such as coriander, chamomile and bean sprouts. Because apigenin has anti-inflammatory, anti-oxidation and anti-cancer effects, it has received extensive attention in the fields of food, biology and medicine. However, the solubility of apigenin in water is only 2.16 μg / mL, and its poor water solubility limits its application in practical processes, resulting in low bioavailability. In recent years, aggregates based on surfactants, such as cyclodextrin-modified microemulsions, liposomes, polymer micelles, nanoparticles, etc., have been widely used as carriers to improve the solubility and availability of apigenin. Research. [0003] Microemulsions are usually transparent or translucent thermodynamically stable self-assembly sy...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/28A61K47/14A61K47/10A61K47/02A61K31/352A61P39/06
Inventor 王仲妮董爽爽
Owner 海生健康科技(青岛)有限公司
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