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Polyvinyl alcohol crosslinked thiolated hyaluronic acid/polyvinyl alcohol film and preparation method and application thereof

A technology of polyvinyl alcohol film and hyaluronic acid, which is applied in the field of thiolated hyaluronic acid/polyvinyl alcohol film and its preparation, can solve the problems of backing layer rupture, drug loss, low swelling, etc., and achieve release prevention, The effect of dense structure and good swelling performance

Inactive Publication Date: 2012-08-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used materials for the backing layer are mainly ethyl cellulose, etc. This type of material can effectively prevent the drug from being released from the backing layer and control the one-way release of the drug, but because ethyl cellulose is difficult to dissolve in water, the swelling property is low. When preparing a double-layer or multi-layer structure carrier with a material with good swelling property, due to the large difference in swelling property of the material, the backing layer will crack and fall off in the aqueous solution, resulting in drug loss

Method used

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  • Polyvinyl alcohol crosslinked thiolated hyaluronic acid/polyvinyl alcohol film and preparation method and application thereof
  • Polyvinyl alcohol crosslinked thiolated hyaluronic acid/polyvinyl alcohol film and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh 0.02 g of hyaluronic acid-cysteine ​​(the molecular weight of hyaluronic acid is 1×10 5 ), put it in a weighing bottle (25 mm×25 mm), add 1 mL of water to dissolve, and obtain a hyaluronic acid-cysteine ​​solution with a concentration of 2%; add 0.1 g of PVA, and add 10 μL of 5% GA after dissolving , sealed at room temperature for 12 h, and vacuum-dried at room temperature in a vacuum drying oven to obtain a PVA-crosslinked hyaluronic acid-cysteine / PVA film.

Embodiment 2

[0026] Weigh 0.01 g of hyaluronic acid-cysteamine (the molecular weight of hyaluronic acid is 5×10 5 ), put it in a weighing bottle (25 mm×25 mm), add 1 mL of water to dissolve, and obtain a hyaluronic acid-cysteine ​​solution with a concentration of 1%; add 0.05 g of PVA, and add 10 μL of 5% GA after dissolving , sealed at room temperature for 12 h, and vacuum-dried at room temperature in a vacuum drying oven to obtain a PVA-crosslinked hyaluronic acid-cysteamine / PVA film.

Embodiment 3

[0028] Weigh 0.01 g of hyaluronic acid-homocysteine ​​(the molecular weight of hyaluronic acid is 1.5×10 6 ), put it in a weighing bottle (25 mm×25 mm), add 1 mL of water to dissolve, and obtain a hyaluronic acid-homocysteine ​​solution with a concentration of 1%; add 0.02 g of PVA, and add 4 μL of 5% GA, sealed at room temperature for 12 h, and vacuum-dried at room temperature in a vacuum drying oven to obtain a PVA-crosslinked hyaluronic acid-homocysteine / PVA film.

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Abstract

The invention belongs to the technical field of the macromolecular material and particularly discloses a polyvinyl alcohol crosslinked thiolated hyaluronic acid / polyvinyl alcohol film and a preparation method and application thereof. The preparation method comprises the following steps: using biodegradable thiolated hyaluronic acid and polyvinyl alcohol (PVA) as raw material to crosslink with PVAby using glutaraldehyde (GA), and performing vacuum drying at the room temperature to prepare the polyvinyl alcohol crosslinked thiolated hyaluronic acid / polyvinyl alcohol film. The film is used as the back lining layer of the drug carrier to control the one-way release of the drug. The invention expands the application range of the polymer film and provides a new back lining layer material for the drug carrier.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a polyvinyl alcohol cross-linked mercaptolated hyaluronic acid / polyvinyl alcohol film and a preparation method and application thereof. Background technique [0002] In order to improve the effective absorption of drugs at the absorption site and reduce the loss of drugs, a multi-layer drug delivery carrier with a non-permeable backing layer can be designed to achieve the purpose of unidirectional drug release and improve drug bioavailability. The backing layer is introduced into carriers such as films, tablets, and hydrogels to form a double-layer or multi-layer carrier structure, which has been widely used in oral, buccal, nasal, and transdermal drug delivery routes to effectively improve drug absorption. At present, the commonly used materials for the backing layer are mainly ethyl cellulose, etc. This type of material can effectively prevent the drug fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08J3/24C08L29/04C08L5/08C08K5/07A61K47/36
Inventor 印春华丁洁英唐翠
Owner FUDAN UNIV