Surface-modified nanoparticles
A technology for surface modification of nanoparticles and nanoparticles, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, and can solve problems such as the inconspicuous ability of nanoparticles
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[0102] Objects and advantages of this invention are further illustrated by the following examples, but the particular materials and amounts thereof recited in these examples, as well as other conditions and details, should not be construed to unduly limit this invention. These examples are illustrative only, and are not intended to limit the scope of the appended claims.
[0103] All parts, percentages, ratios, etc. in the examples and in the rest of the specification are by weight unless otherwise indicated. Solvents and other reagents used were obtained from Sigma-Aldrich Chemical Company (St. Louis, MO) unless otherwise indicated. All chemicals and reagents were used without further purification unless otherwise indicated.
[0104] Material
[0105] Calcium chloride hexahydrate (98% purity), manganese(II) chloride tetrahydrate (99.99% purity), crystalline phosphoric acid (99% purity; Fluka) and methyltrimethoxysilane (98% purity) were all obtained from Sigma - Aldrich ...
example 1 to 16 and comparative example C1 to C3
[0127] Surface Modified Nanoparticles
[0128] Component Mixture 1 listed in Table 1 below was mixed with Component Mixture 2 in a three-necked round bottom reaction flask connected to a condenser via a Dean-Stark receiver; subsequently under reaction conditions A listed in Table 1 , and the resulting reaction mixture was stirred under a stream of nitrogen until one cloudy layer and one clear layer were observed in the reaction flask. At this temperature, the component mixture 3 listed in Table 1 was added. The reaction mixture was then maintained under reaction condition B shown in Table 1. A 4-fold excess of methanol (by volume) was added to the warm reaction mixture, resulting in the precipitation of a white solid. The mixture was centrifuged and the solid was washed with ethanol to obtain a pure metal phosphate powder. The powder was dried in an oven (200° C.) for 15 minutes to obtain a dried metal phosphate powder. The redispersibility properties of the dried powder...
example 17 to 19 and comparative example C4 and C5
[0139] Pharmaceutical compositions comprising surface-modified nanoparticles
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