Sodium alga acid composition and application thereof

A technology of sodium alginate and its composition, which is applied in the sodium alginate composition and its application field, can solve the problems of different hemostasis mechanisms and unsatisfactory hemostasis speed, and achieve the effect of promoting blood coagulation and simple preparation process

Active Publication Date: 2011-06-15
FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For example, in the prior art, an existing patent (Application No. 20061024198.2) uses sodium alginate as one of the reaction components, and its final product is calcium alginate microspheres, which are used to promote wound healing during minor trauma, but its composition must be It is mainly chitosan, sodium alginate and calcium chloride, among which sodium alginate is only used as a precursor to synthesize cross-linked hydrogel microspheres calcium alginate with calcium chloride, and then compounded with chitosan to form The hemostatic microsphere powder, whose medicinal ingredient is calcium alginate, is still essentially different from the direct use of sodium alginate in the present invention, and the hemostatic time is also limited by the formation of hydrogel, so the hemostatic mechanism is not the same , the speed of hemostasis is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-21

[0064] Example 1-21: Preparation of Sodium Alginate Composition Powder

[0065] Sodium alginate powder (particle size is 60 meshes, except Examples 20 and 21, M / G value is 0.4) is mixed with calcium chloride, calcium gluconate or zinc sulfate powder respectively according to the component distribution ratio of Table 4, put into Mix well in a mortar. After adding absolute ethanol for soaking, the product was poured out, suction-filtered with a Buchner funnel, vacuum-dried at 60° C., and sterilized by Co60 to prepare sodium alginate composition powder (particle size: 60 mesh).

[0066] Table 4 Sodium Alginate Composition

[0067]

[0068]

[0069] Experiment 5: Hemostasis animal experiment

[0070] Male Wistar rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium at 30 mg / Kg, groin hair was removed, alcohol cotton balls were sterilized, the thigh skin was cut, and the femoral artery was bluntly separated to expose 2-3 cm. Put an impermeable clot...

Embodiment 5

[0079] From the results of Example 5, Examples 7-10 and Examples 11-14, it can be seen that there is no significant change in the hemostasis time of the composition with zinc ions added. However, 24 hours after the wound was sutured in rats, the wound healing was better than that without zinc ions;

[0080] Comparing the results of Example 5 with Examples 15-18, it can be seen that after adding calcium ions and zinc ions, the speed of hemostasis is effectively accelerated. Example 7 and Example 15 added zinc ions under the condition that the amount of calcium ions was basically the same, and the results showed that the hemostasis time was not much different, but the wound healing was better than that of the group without zinc ions.

[0081] It can be seen from the comparison of the results of Examples 19-21 that when M / G is equal to 0.4, the hemostatic onset is fast;

[0082] To sum up, choosing to add about 1% calcium ion sodium alginate combination is the best choice for he...

Embodiment 22

[0083] Example 22: Preparation of Sodium Alginate Hemostatic Dressing

[0084] Sodium alginate with a viscosity of 300MPas was prepared into a 10% solution, which was subjected to high pressure treatment for later use. After mixing the sodium alginate solution and the 20% calcium chloride solution in a volume ratio of 10:1, glycerin and lysine were added. After removing excess water, it is freeze-dried to form a hemostatic dressing.

[0085] According to the method of experiment 5, the hemostasis time was measured to be 25±1.37s, and the blood loss was 0.1287±0.2321g (n=4). The wound was basically healed without infection at 24 hours after operation.

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Abstract

The invention relates to application of a hemostasis material of sodium alga acid and sodium alga acid added calcium salt or zinc salt composition in wound surface hemostasis. The sodium alga acid composition comprises 50-100 parts by weight of sodium alga acid and 0.5-50 parts by weight of calcium salt. The invention also provides a hemostasis material prepared from the sodium alga acid composition and at least one pharmaceutically acceptable solvent, carrier and / or excipient. The sodium alga acid composition and the hemostasis material in the invention have the characteristics of rapid hemostasis, good biocompatibility, biodegradation absorbability, simpleness in treatment, no need of debridement, low cost and the like, and is suitable for the hemostasis in the wound surface, especially in war wound surface.

Description

Technical field: [0001] The invention relates to a new application of sodium alginate directly as a hemostatic material, a sodium alginate composition added with calcium salt and / or zinc salt, a hemostatic material containing the sodium alginate composition and their application in wound surface hemostasis. Background technique: [0002] The treatment of war wounds focuses on early treatment at the front of the battlefield and on the way to evacuation, prolonging the "golden hour" treatment time limit, and reducing the rate of blood loss and casualties. At present, the main treatment measures for war wounds are physical compression hemostasis (such as gauze, tourniquet, etc.), but the disadvantage of compression hemostasis is that if the tourniquet is too tight, it will easily cause tissue ischemia and necrosis, and excessive force may cause rib fractures; Moreover, when bleeding occurs in a traumatized patient with important organ injury (heart, brain, lung, liver, spleen, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61K31/734A61K9/14A61K9/12A61P7/04C08B37/04C08L5/04
Inventor 于群李伟静贺敏王璇琳陈学峰张公庆王靖
Owner FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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