Oral administration medicament for treating depression

Abstract

The invention relates to an oral administration medicament for treating depression, which is prepared from the following Chinese medicinal raw materials in part by mass: 1 to 5 parts of red ginseng, 5 to 20 parts of astragalus, 3 to 10 parts of Chinese magnoliavine fruit and 8 to 15 parts of hypericum perforatum L by the conventional preparation method. The oral administration medicament can be capsules or tablets or granules or oral liquid in pharmaceutics. Medicinal effect experiments prove that the medicament can improve the appetite, interest, memory acquisition and memory retention capability, activity and exploration capability of chronic depressed model rats obviously, can improve the content of 5-HT and NE in brains of the chronic depressed model rats obviously, and promote that an action mechanism of depression resistance of the medicament is possibly associated with the inhibition of reuptake on 5-HT and NE, and the effect of the medicament is equivalent to that of fluoxetine hydrochloride. The medicament has a certain effect of anxiety resistance, and the effect is similar to that of diazepam. Pharmacological experiments and clinical observation prove that the medicament has high anti-depression effect and a certain effect of anxiety resistance.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worry that you have various diseases, and feeling that you are suffering from various diseases in your body. Discomfort, and in severe cases, suicidal thoughts and behaviors may appear. Depression is mainly based on depressed mood, slow thinking and decreased willpower, and there are various somatic symptoms in most cases. These include sleep disturbances (difficulty falling asleep, light sleep, waking up early, or feeling sleepy when others thought he was sleeping well), fatigue or loss of energy, decreased appetite (70% of people with depression experienc...

AI Technical Summary

Problems solved by technology

[0005] The disadvantages of Western medicine are: the curative effect on various physical discomfort symptoms is not obvious, which makes the patient's compliance poor; the side effects are many and serious, which makes it difficult for patients to accept; in addition, the price of new drugs is relatively expensive, which makes it difficult for patients to bear

Patients with clinical depression are often accompanied by anxiety symptoms, and there are few research results on the anti-anxiety effect of traditional Chinese medicine for the treatment of depression

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