New crystal form of S-oxiracetam and preparation method thereof

A crystal form and crystal technology, which is applied in the field of new crystal form of S-oxiracetam and its preparation, can solve the problems of uncrystallized form research, crystallization method disclosure, etc., and achieve the effect of good stability and controllable product quality

Inactive Publication Date: 2011-06-22
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent WO9306826A1 describes that the pharmacological action of S configuration oxiracetam is stronger than its R configuration; the document Tetrahedron: Asymmetry, 1992, 3(11), 1431-1440 discloses the synthesis method of S configuration oxiracetam, However, its crystallization method has not been publicly described, and its crystal form has not been studied

Method used

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  • New crystal form of S-oxiracetam and preparation method thereof
  • New crystal form of S-oxiracetam and preparation method thereof
  • New crystal form of S-oxiracetam and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 2 g of S-oxiracetam was heated and dissolved in 60 ml of methanol, cooled to crystallize, filtered with suction, and dried in vacuum at 50° C. to obtain crystalline form I of S-oxiracetam.

Embodiment 2

[0028] 1.6 g of S-oxiracetam was dissolved by heating with 20 ml of ethanol and 2 ml of water, crystallized by cooling, suction filtered, and vacuum-dried at 50° C. to obtain crystal form I of S-oxiracetam.

Embodiment 3

[0030] 2.7 g of S-oxiracetam was dissolved by heating with 20 ml of methanol and 2 ml of water, crystallized by cooling, suction filtered, and vacuum-dried at 50° C. to obtain crystalline form I of S-oxiracetam.

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PUM

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Abstract

The invention discloses a new crystal form of S-oxiracetam and a preparation method thereof. The new crystal form is characterized in that: characteristic absorption peaks exist when a reflected angle 2 theta is about 12.1, 17.5, 19.7, 21.4, 24.7, 29.3 and 32.0 in an X-ray powder diffraction pattern.

Description

technical field [0001] The invention relates to a new crystal form of S-oxiracetam and a preparation method thereof. Background technique [0002] S-oxiracetam (s-oxiracetam), chemical name: (S)-4-hydroxy-2-carbonyl-1-pyrrolidone acetamide, chemical structural formula is as follows: [0003] [0004] Oxiracetam is a new generation of brain metabolism improving drug, which belongs to a new type of pyrrolidone derivatives. It has been listed in Europe, the United States, Japan and South Korea and is widely used in clinical practice. It has good curative effect on intracranial infection, dementia, and brain degenerative diseases. Through extensive pharmacological research and clinical trials, it has been proved that its effect is 2 to 5 times stronger than that of piracetam. It is a nootropic drug with broad application prospects. [0005] In the molecular structure of oxiracetam, the carbon atom at the 4th position of the pyrrolidone ring is an asymmetric carbon atom. Pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/273A61K31/4015A61P9/00A61P25/28
Inventor 姚勇敢
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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