Fluorescence molecule imaging device

A fluorescent molecular imaging and imaging technology, which is used in medical science, sensors, diagnostic recording/measurement, etc., can solve the problems of the quantum efficiency of the camera, changing the focal length of the lens and the object distance, and large attenuation of the excitation light intensity. Achieve the effect of simple and easy-to-use design, reduced detection errors, and high fluorescence excitation efficiency

Active Publication Date: 2011-06-29
INST OF AUTOMATION CHINESE ACAD OF SCI
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Problems solved by technology

This method has many disadvantages. For example, after the excitation light is reflected once, the intensity of the excitation light is greatly attenuated, and the ratio of useful light is very low.
In addition...

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  • Fluorescence molecule imaging device
  • Fluorescence molecule imaging device
  • Fluorescence molecule imaging device

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Embodiment Construction

[0010] The present invention will be further described below in conjunction with the accompanying drawings.

[0011] like figure 1 As shown, the technical solution of the fluorescent molecular imaging device of the present invention includes an excitation module and an imaging module; wherein: the excitation module is composed of an excitation light source 1, an excitation filter wheel 2, an excitation filter 3, and a multi-bundle optical fiber 4; The module consists of a CCD camera 5, a lens 6, a lens adjustment unit 7, an emission filter wheel 8, an emission filter 9, and an imaging cavity 10; the exit of the excitation light source 1 is connected to the excitation filter wheel 2, and multiple excitation filters 3 are embedded In the excitation filter wheel 2; a plurality of excitation filters 3 are connected to the input end of a multi-bundle optical fiber 4, the excitation light of the excitation light source 1 is filtered by the excitation filter 3 in the excitation filte...

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Abstract

The invention provides a fluorescence molecule imaging device, comprising an excitation module and an imaging module, wherein the excitation module consists of an exciting light source, an exciting filter wheel, an exciting optical filter and a plurality of beams of optical fibers. The imaging module consists of a CCD (Charge Coupled Device) camera, a lens, a lens adjusting unit, an emitting filter wheel, an emitting optical filter and an imaging cavity. The exciting light source generates exciting light, which passes through the exciting optical filter in the exciting filter wheel, and then the exciting light of some set wave band is irradiated to the detected object evenly via one optical fiber; the detected object is excited to generate the fluorescence signal with wavelength longer than that of the exciting light; the signal passes through the emitting optical filter of the emitting filter wheel set in front of the lens, then the specific emitting fluorescence signal is received by the CCD camera, converted into an image signal and displayed in a computer. The fluorescence molecule imaging device is simple in design and structure, convenient in operation, low in cost, and is widely applied to the fields such as medical image and the like.

Description

technical field [0001] The invention relates to an imaging device, in particular to a device for imaging fluorescent molecules by using excitation light of a specific wavelength band, and the device can be used to acquire surface information of a detected object. Background technique [0002] With the rapid development of genomics, proteomics and disease genomics, the diagnosis of diseases is developing from the traditional observation of disease characterization and routine biochemical experiment detection to the recognition of microscopic features at the gene and molecular levels. Technology can deeply understand the occurrence and development process of diseases from the level of genes and proteins, and can realize a holistic, continuous, non-invasive specific detection method that cannot be replaced by existing microscopic analysis. The theory of biological molecular imaging and its technology in vivo will provide a new Prevention, diagnosis and treatment tools. Compare...

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Application Information

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IPC IPC(8): A61B5/00
Inventor 田捷薛贞文杨鑫秦承虎杨祥
Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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