10 results about "Excitation filter" patented technology

The utility model discloses a multicolor excitation fluorescence microscope, and belongs to the field of microscopes. Comprising a first numerical control light source; the carrying seat is arranged below the first numerical control light source; the opening is formed in the carrying plate; the carrying plate is arranged on the carrying seat; the numerical control objective lens converter is arranged below the loading plate, and the numerical control objective lens converter corresponds to the opening; the chroscope box is connected to the interface of the numerical control objective lens converter; the dichroscope is movably arranged in the dichroscope box; the X-ray plate box is arranged at the bottom of the color mirror box; the movable sheet is arranged on the X-ray plate box in a sliding manner; the excitation optical filter is movably arranged on the moving sheet; the second numerical control light source is arranged at the bottom of the light sheet box and corresponds to the excitation light filter; and the high-definition automatic focusing camera is connected with the interface of the chroscope box. The beneficial effect of the utility model is that the multicolor excitation fluorescence microscope is provided.

The invention relates to an assembly (12) for a converter (13) of a drive unit (10), and to a converter (13). The assembly (12) comprises a control and evaluation unit (38) and an excitation circuit (34). The excitation circuit (34) comprises an asymmetrical half-bridge (48), which has at least a first power switch (54A) and a second power switch (54B). The excitation circuit (34) has a first excitation line (60A) and a second excitation line (60B) for the drive unit (10). The first power switch (54A) is associated with the first excitation line (60A), and the second power switch (54B) is associated with the second excitation line (60B). The excitation circuit (34) has an excitation filter (62), which has a first RC element (70A) coupled to the first excitation line (60A) and a second RC element (70B) coupled to the second excitation line (60B). The control and evaluation unit (38) is connected to the RC elements (70A, 70B) in such a way that a switch-on transient and / or a switch-off transient of the power switch (54A, 54B) associated with the respective excitation line (60A, 60B) can be tapped. The control and evaluation unit (38) is designed to detect a fault state on the basis of the tapped switch-on transient and / or switch-off transient.

The application discloses a non-invasive multi-channel multi-parameter biological signal detection device and a use method thereof, relates to the technical field of biological sample signal collection, and comprises the following parts: a plurality of filter plates with different wave bands are uniformly arranged on an excitation filter plate switching device and a signal collection filter plate switching device, and a light source is arranged at one end of the excitation filter plate switching device; a detector is arranged at the light source of one end of the signal collection filter plate switching device; an excitation optical fiber bundle and a signal collection optical fiber bundle are arranged in opposite intervals; a plurality of detection heads are arranged between the excitation optical fiber bundle and the signal collection optical fiber bundle, the detection heads are arranged at one end of the excitation optical fiber bundle away from the excitation filter plate switching device, and a plurality of groups of the detection heads are arranged in the direction of a multi-well plate. The non-invasive multi-channel multi-parameter biological signal detection device and the use method thereof can solve the problems of low flux, low efficiency and single type of detected signals in the current biological signal detection field.

This invention discloses an illumination system and an optical detection system suitable for nucleic acid detection devices. The illumination system includes a light source module, a field lens system, an excitation filter wheel, and an illumination prism module. The illumination prism module includes a beam splitter, multiple reflectors, at least two Dowell prisms, and at least two tilting reflectors. The light source module emits a beam to the field lens system for beam straightening and shaping, then filters it via the excitation filter wheel, and finally directs the beam into the beam splitter of the illumination prism module to separate it into at least two beams. The directions of the at least two beams are adjusted by the multiple reflectors, ensuring they pass through the at least two Dowell prisms and then through the at least two tilting reflectors, so that the at least two beams illuminate the sample's illumination area from different directions.

The utility model provides a fluorescence switching device for medical imaging equipment, which comprises a motor and a turntable body, the turntable body comprises a top plate, the motor is connected with the top plate, and a plurality of light filtering components are arranged in the circumferential direction of the top plate; the light filtering assembly comprises an excitation light filter support and a dichroscope support connected with the excitation light filter support, an excitation light filter is arranged on the excitation light filter support, a dichroscope is arranged on the dichroscope support, and the excitation light filter support is fixedly connected with the edge of the top plate; the excitation optical filter is located on one side of the dichroscope in the horizontal direction, and a reflection optical filter is arranged on the top plate. The structure of the light filtering assembly is greatly simplified, the size and the structural complexity of the light filtering assembly are greatly reduced, the weight of the light filtering assembly is effectively reduced, more light filtering modules can be installed on one rotary table body, and more than ten light filtering assemblies can be installed on one rotary table body at the same time. And the switching requirement of a large number of light filtering assemblies can be effectively met.

The invention relates to an assembly (12) for a converter (13) of a drive unit (10) and a converter (13). The assembly (12) comprises a control and evaluation unit (38) and an excitation circuit (34). The excitation circuit (34) comprises an asymmetrical half-bridge (48) with at least one first circuit breaker (54A) and a second circuit breaker (54B). The excitation circuit (34) has a first excitation line (60A) and a second excitation line (60B) for the drive unit (10). The first circuit breaker (54A) is assigned to the first excitation line (60A) and the second circuit breaker (54B) is assigned to the second excitation line (60B). The excitation circuit (34) has an excitation filter (62) which has a first RC element (70A) coupled to the first excitation line (60A) and a second RC element (70B) coupled to the second excitation line (60B).The control and evaluation unit (38) is connected to the RC elements (70A, 70B) such that a switch-on transient and / or a switch-off transient of the circuit breaker (54A, 54B) assigned to the respective excitation line (60A, 60B) can be tapped. The control and evaluation unit (38) is configured to detect a fault condition based on the tapped switch-on transient and / or switch-off transient.

A system for sample holder scanning is provided. The system comprises: a light source; a multi-band excitation filter configured to select light of at least two excitation bands for a fluorescent dye used in the sample holder. The system further includes: a multiband dichroic filter configured to reflect light of the at least two excitation bands; and a multi-band emission filter configured to transmit the fluorescent emission light of at least two bands from each reaction site of the sample holder. The multiband dichroic filter is further configured to transmit the fluorescent emission light of the at least two bands. The system also includes an optical sensor configured to detect the fluorescent emission light of the at least two wavebands to generate an image of the sample holder.

An adaptive robotic system for gene editing and cell manipulation is provided. The system (100) of the present invention comprises a multi-axis robotic assembly (102) with piezoelectrically actuated flexure-based joints arranged in a parallel kinematic architecture to enable submicron probe positioning relative to target cells. A mechanical end-effector mount (104) features force-limiting couplings to prevent cell damage and interchangeably mounts cell manipulation tools such as microinjection needles, nanopipettes, and electroporation electrode pairs. A microfluidic dispensing assembly (106) with pressure-controlled reagent channels and piezoelectrically actuated microvalves delivers volumetric delivery of genetic material with nanoliter precision. An optical imaging assembly (108) with variable focus optics, fluorescence excitation filters, and a Raman spectroscopic detector enables real-time visualization and confirmation of intracellular delivery events.

The utility model discloses a multichannel fluorescent dye optical filter combination for FISH (fluorescence in situ hybridization) detection, which comprises an excitation optical filter, an emission optical filter and a color separation optical filter, and the excitation optical filter, the emission optical filter and the color separation optical filter respectively comprise a glass substrate arranged at the bottommost layer; the glass substrate comprises a plurality of high-refractive-index coating layers and a plurality of low-refractive-index coating layers, and each high-refractive-index coating layer and each low-refractive-index coating layer are sequentially arranged on the glass substrate according to alternate sputtering; the multi-channel fluorescent dye filter combination is suitable for simultaneously detecting three fluorescent markers of enhanced cyan fluorescent protein (ECFP), fluorescein isothiocyanate (FITC) and cyan pigment 3 (CY3).

This application discloses a polymerase chain reaction (PCR) detector and its fluorescence detection device. The fluorescence detection device includes a sample reactor, an excitation component, and a fluorescence receiving tube, all fixedly mounted, as well as an excitation filter module, a detection filter module, and a control module, all driven by a driving device. The excitation filter sequentially passes through the optical path of the excitation component, and the corresponding detection filter simultaneously passes through the optical path of the fluorescence receiving tube. The fluorescence receiving tube receives fluorescence signals from at most one sample reactor at a time. This application can quickly, efficiently, and accurately complete multi-channel fluorescence detection, while also featuring a simple structure, small size, fast detection speed, high stability, and a significantly improved signal-to-noise ratio.