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Method for determining Adapalene midbody-related substances by using high performance liquid chromatography

A technology of high performance liquid chromatography and related substances, which is applied in the field of separation and analysis of related substances of adapalene intermediates by high performance liquid chromatography, can solve the problems of no literature reports, no patent application reports, etc., and achieve accurate and reliable results and methods Simple and fast, quality controllable effect

Inactive Publication Date: 2011-07-06
北京德众万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no literature report on the HPLC analysis method of this compound, and there is no patent application report

Method used

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  • Method for determining Adapalene midbody-related substances by using high performance liquid chromatography
  • Method for determining Adapalene midbody-related substances by using high performance liquid chromatography
  • Method for determining Adapalene midbody-related substances by using high performance liquid chromatography

Examples

Experimental program
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Embodiment 1

[0027] figure 1 Embodiment 1, ammonium acetate solution-methanol (12: 88) adapalene intermediate and intermediate mixed sample HPLC

Embodiment 2

[0028] figure 2 Embodiment 2, ammonium acetate solution-methanol (12: 88) adapalene intermediate high performance liquid chromatography

specific Embodiment approach

[0029] The specific embodiment: the following examples are used to further understand the present invention, but are not limited to the scope of this implementation

[0030] Example 1

[0031] Instruments and Conditions

[0032] High performance liquid chromatography: Japan Shimadzu: LC-10ATvp, SPD-10Avp

[0033] Chromatographic column: Octylsilane bonded silica gel as filler (250mm×4.6mm, 5μm)

[0034] Mobile phase: ammonium acetate solution-methanol (12:88)

[0035] Flow rate: 1.0ml / min

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Abstract

The invention discloses a method for determining the separation and the analysis of Adapalene midbody-related substances, wherein the Adapalene midbody-related substances are separated and analyzed by using an octyl silane-bonded silica gel as a filler in a chromatographic column of 250mm multiplied by 4.6mm and 5 microns and using an ammonium acetate solution-organic modifier as mobile phase.

Description

technical field [0001] The present invention relates to a high-performance liquid chromatography separation and analysis method, in particular to a high-performance liquid chromatography separation and analysis method for related substances of adapalene intermediates. Background technique [0002] Adapalene, a retinoid compound with anti-inflammatory properties, is a new skin drug for acne. Its intermediate structural formula: [0003] [0004] Molecular formula: C 27 h 26 o 3 , molecular weight: 398.50 [0005] The HPLC analysis method of this compound has no bibliographic report, also has no patent application report. [0006] This method effectively carries out purity analysis to the adapalene intermediate, and this test adopts common chromatographic column (C 8 Chromatographic column) quickly and accurately realizes the determination of related substances of adapalene intermediates, thereby realizing the control of impurities in adapalene intermediates, ensuring...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/50
Inventor 张燕康彦龙刘秋叶
Owner 北京德众万全医药科技有限公司
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