Multi-mode micro mixer chip and high-flux mixing and flexible mixing method

Abstract

The invention discloses a multi-mode micro mixer chip which comprises n sample inlets, m sample outlets, an upper substrate and a lower substrate, wherein the upper substrate is fixedly connected with the lower substrate into a whole through a runner layer; the upper substrate comprises an upper substrate base material layer and an upper substrate conductive film arranged on the lower surface of the upper substrate base material layer; the runner layer comprises a curved runner and a mixing cavity connected with one end of the curved runner, the other end of the curved runner is connected with the n sample inlets, and the other end of the mixing cavity is connected with the m sample outlets; and the curved runner comprises a main curved runner and a sudden expand structure arranged on the main curved runner. The invention can realize high-flux mixing of samples under the condition of higher flow velocity, realizes low-damage flexible mixing of easy-damageable biological active materials under the condition of lower flow velocity, and overcomes the defects of complicated structure and poor flexibility and generality of the traditional micro mixer to a certain degree.

Description

technical field [0001] The invention relates to a micro-mixer chip, in particular to a multi-mode micro-mixer chip and high-flux mixing and flexible mixing methods. Background technique [0002] Micromixer is an important component in Lab-on-a-Chip (LOC). It is widely used in analytical chemistry, biological research, synthetic chemistry, and disease diagnosis because it can achieve precise micro-mixing of samples. and environmental monitoring. The micro-mixer based on microfluidic technology has been widely concerned due to the advantages of simple manufacturing process and low cost. However, due to the limitation of laminar flow (Reynolds number in general applications) The diffusion effect on the contact surface is used to achieve mixing, which is extremely inefficient and cannot achieve the mixing of micro-nano particles. How to achieve fast and efficient mixing of samples at a low Reynolds number has always been a hot and difficult point in the research of micromixers...

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Problems solved by technology

[0003] Aiming at the deficiencies in the prior art, the purpose of the present invention is to provide a multi-mode micro-mixing chip combined with structure-induced fluid vortices and dynamic virtual electrodes and a high-throughput mixing and flexible mixing method, which can be used at higher flow rates Under certain circumstances, high-throughput mixing of samples can be realized, and low-damage and flexible mixing of easily damaged bioactive materials can be realized under the condition of low flow rate, and to a certain extent, it overcomes the complicated structure, poor flexibility and poor versatility of the current micro-mixer. Shortcomings

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