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Brown adipose tissue targeted polypeptide and applications thereof

A brown adipose tissue, targeted technology, applied in the field of biomedicine, to achieve the effects of small spatial position changes, easy quality monitoring, and easy synthesis

Inactive Publication Date: 2011-07-13
JIANGSU PROVINCE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, no such carrier for brown adipose tissue-targeted therapy has been reported at home and abroad.

Method used

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  • Brown adipose tissue targeted polypeptide and applications thereof

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Experimental program
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Effect test

Embodiment 1

[0013] Take a four-week-old C57BL / 6J male mouse, inject 10ul of peptide labeled with green fluorescent FITC (solution concentration: 1mM) into the mouse body through the tail vein of the mouse, and kill the mouse by dislocation of the neck after 10min, and take fresh tissue (white adipose tissue) tissue, brown adipose tissue, muscle tissue, liver tissue), immediately protected from light by embedding in paraffin, sectioning, and directly observing the fluorescence under a laser confocal microscope, the results showed that only in the capillary network of brown fat was the highest expression of FITC-labeled green fluorescence Obviously, suggesting that the polypeptide can indeed be targeted to brown adipose tissue (results such as figure 1 shown).

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Abstract

The invention relates to the technical field of biomedicine, in particular to a brown adipose tissue targeted polypeptide and applications thereof. The polypeptide of the invention is prepared by connecting amino with the C-terminus of the polypeptide CKGGRAKDC, namely CKGGRAKDC-NH2. The polypeptide with the brown adipose tissue characteristic affinity of the invention can carry therapeutic drugswith different molecular weights to the brown adipose tissue and also have potential scientific research and clinical application values when used as the specific carrier for curing obesity and body metabolic disorder.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a brown adipose tissue targeting polypeptide and its application. Background technique [0002] With the development of social economy and the change of people's lifestyle, obesity has become a global epidemic disease, which in turn causes obesity-related diseases (type II diabetes, hypertension, hyperlipidemia, coronary atherosclerotic heart disease, etc.) The incidence and fatality rate have also risen sharply, which has brought a heavy social and economic burden to our society. Therefore, the research and development of new obesity treatment methods is particularly important. [0003] Obesity is mainly manifested as the excessive generation and accumulation of white adipose tissue, and a large number of previous research results at home and abroad have shown that the increase of white fat (including subcutaneous / visceral fat) is the most critical factor for the occurrence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K47/42
Inventor 丁国宪刘娟
Owner JIANGSU PROVINCE HOSPITAL
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