Industrial method for efficiently producing lycopene crystals

Abstract

The invention relates to an industrial method for purifying natural extracts, in particular to an industrial method for efficiently producing lycopene crystals. The method comprises the following steps of: (1) mixing 6-15 percent of lycopene oleoresin with a diolefine solvent in the mass ratio of 1:(3-7) and stirring the mixture to dissolve the mixture into mixed liquor; (2) standing the mixed liquor at the temperature of between 10 DEG C below zero and 20 DEG C and centrifuging the mixed liquor to obtain viscous paste; (3) mixing the viscous paste with the paraffin solvent, standing and centrifuging to obtain paste; (4) performing vacuum drying on the paste and removing solvent residues to obtain the lycopene crystals; and (5) and performing vacuum low-temperature concentration on filtrate obtained by centrifuging in the step (2) and the step (3) to obtain low-content lycopene oleoresin. The method has low environmental requirements, and an enriched high-content lycopene oleoresin component can be efficiently and continuously separated.

Description

technical field [0001] The invention relates to an industrial method for purifying natural extracts, in particular to an industrial method for efficiently producing lycopene crystals. Background technique [0002] Lycopene is well-known for its superior antioxidant function. It is made into soft capsules, microcapsules, oil-soluble suspensions, tablets, powders, injections and other products in various forms and specifications. It is used in the medical and health care markets. Over the years, it has been unanimously favored by the domestic and foreign health care product markets. [0003] Lycopene itself is fat-soluble and is not easily absorbed by the human body. Generally, it needs to be prepared into a water-dispersible product for application. In practical applications, various preparation products are the most common, and their stability must be enhanced by embedding. The raw materials used for the production of preparation products must use high-purity lycopene crys...

AI Technical Summary

Problems solved by technology

[0004] In the patent with publication number CN1775867A, lycopene is mixed with alcohol solution, stirred, filtered, and dried to obtain a refined lycopene product. However, it is difficult to filter lycopene, so we can only choose a filter with a larger pore size. It takes more than 10 hours in total. On the one hand, it takes a long time and the efficiency is low. On the other hand, it cannot effectively intercept high-content components. The content of 19-65% can explain this problem

In the patent with the publication number CN1807410A, lycopene was repeatedly crystallized three times to obtain high-purity crystals. Recrystallization is a process of losing high-content components. The yield is difficult to guarantee, and the production efficiency can also be imagined

In the patent with the publication number CN1687239A, its crystallization temperature is controlled relatively high, which is not conducive to the enrichment speed and effect of high-purity lycopene, and also uses the process of filtration and crystallization, and the production efficiency and yield must not be guaranteed.

In the patent with the publication number CN1405235A, a technology for separating and purifying lycopene by reverse-phase chromatographic column is disclosed, which can prepare products with a purity of more than 99%, but requires expensive chromatographic equipment, low production efficiency, and small output, which is not suitable for Industrial production

[0005] In short, in the preparation methods of high-purity lycopene, most of them use low-temperature environment, and follow the method of crystallization, recrystallization, filtration, and drying. The process is lengthy and difficult to filter. Generally, the entire production process takes more than 24 hours. Dozens to hundreds of grams of high-purity lycopene crystals. At the same time, because lycopene is easily oxidized and lost, it will take a long time to lose a lot. It is difficult to guarantee the purity and yield of the product, and it is difficult to guarantee the smooth realization of industrialization in terms of cost and efficiency.