Method for preparing hydroxyapatite and hydrotalcite composite material with eggshell as raw material

Abstract

The invention provides a method for preparing hydroxyapatite and hydrotalcite composite material with an eggshell as a raw material. The method comprises the steps of: drying eggshell with the surface being cleaned at the temperature from 313 to 393K for 1 to 12 hours, then calcining the eggshell at the temperature from 573 to 1273K for 1 to 12 hours to obtain a calcination product; (2) adding 0.56 to 5.6g of the calcination product with 50mL of distilled water, uniformly stirring, adding 50mL of NaH2PO4 solution to be mixed with the mixture to obtain reaction liquid I; (3) subjecting the reaction liquid I to ultrasonic treatment for 0.5 to 4.8 hours, adding 50mL of soluble salt solution of trivalent Al or trivalent Fe to obtain reaction liquid II; and (4) subjecting the reaction liquid II to reaction for 0.5 to 4.8 hours, and filtering and drying the reaction product to obtain the hydroxyapatite and hydrotalcite composite material. The preparation method is simple, low in cost and beneficial for actual production. Most importantly, the method allows an inorganic drug carrier to be loaded with multiple drugs simultaneously.

Description

technical field [0001] The invention relates to a preparation method of a composite material. Specifically, it is a method for preparing a composite material of hydroxyapatite and hydrotalcite, which uses eggshells as raw materials. Background technique [0002] Hydrotalcite and hydroxyapatite, as two common inorganic non-metallic materials, have broad application prospects in the fields of drug sustained release, water treatment and anticorrosion. [0003] Especially in the field of drug sustained release, hydroxyapatite, as a common drug sustained release carrier, has good biocompatibility, but because its drug loading is through the hydrogen bond between the hydroxyl group and the drug molecule to be loaded, its It is limited in the following two aspects: 1. Drug loading capacity; 2. Simultaneous loading of multiple drugs. [0004] In addition, due to the precise control of the ratio of Ca / P in the preparation process, the industrial production is limited to a certain e...

AI Technical Summary

Problems solved by technology

[0008] However, there are very few reports on hydrotalcite and hydroxyapatite composite materials. Only Yujiro Watanabe et al. used calcium aluminum hydrotalcite as a precursor to grow hydroxyphosphorus on the surface of hydrotalcite by adding an appropriate amount of phosphate solution. Limestone, and then obtained hydroxyapatite / hydrotalcite composites (Yujiro Watanabe, Toshiyuki Ikoma, HirohisaYamada, Geffrey W.Stevens, J Yusuke Moriyoshi, Junzo Tanaka, and Yu KomatsuzFormation of Hydroxyapatite Nanocrystals on the Surface of Ca Al-Layered DoubleHydroxide J.Am.Ceram.Soc., 16(2010))

However, this method has an irreparable defect. This defect is that in the process of growing hydroxyapatite, the trivalent metal ion aluminum on the hydrotalcite laminate also participates in the formation of hydroxyapatite, and it is impossible to remove it.

As a non-essential trace element of the human body, aluminum is harmful to the human body, which makes the composite material obtained by this method extremely limited in the field of drug sustained release.

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