Neglect-proof drinking immunization tablet for infectious bursal disease (IBD) and preparation method thereof

Abstract

The invention provides a neglect-proof drinking immunization tablet for infectious bursal disease (IBD), which comprises an antigen for IBD, a heat-resistant protective agent and an effervescent material, wherein the antigen for IBD and the heat-resistant protective agent are mixed to prepare a heat-resistant antigen freeze-dried particle, and then, the particle and the effervescent material are evenly mixed and pressed to obtain the neglect-proof drinking immunization tablet. Because a color indicator is added into the effervescent material, by checking whether chicken beak tips are dyed or not, the chicken which does not drink water can be easily found, and the chicken can drink water, thereby effectively avoiding the occurrence of an immunization neglect phenomenon; and a metal chelator, an immune potentiator and a heat-resistant protective agent are added, and a tablet is prepared, thus the vaccine is convenient to transport and store, and the storage time exceeds 24 months. When in use, the vaccine tablet provided by the invention only needs to be put into a proper amount of water for chicken flocks to drink to enable the chicken flocks to be immunized, thereby realizing the effective immunization of IBD of the chicken flocks, ensuring the immunization uniformity, preventing the immunization neglect, and enhancing the vaccine immunization effect. The tablet provided by the invention is most suitable for medium-and-large-sized chicken farms.

Description

technical field [0001] The present invention relates to a new dosage form and preparation method of a vaccine, especially a leak-proof drinking water immunization tablet for chicken infectious bursal disease, which is suitable for drinking water immunization, has an indicator function, can quickly activate the body's immune system, and improve the immune level . Background technique [0002] Chicken infectious bursal disease (Infectious bursal disease, IBD) is a highly contagious disease that is attacked by IBD virus (IBDV) and harms young chickens aged 3 to 8 weeks. The target organ and target cells of IBDV mainly invade the central immune organ of chickens—the B lymphocytes in the bursa tissue, and lead to a decrease in the number of B cells, which in turn causes severe immunosuppression. The direct damage of the disease is a certain mortality rate and elimination rate of infected chickens, while the indirect harm is that subclinical infected chickens or chickens with tol...

AI Technical Summary

Problems solved by technology

Injection immunization is to immunize chickens by dripping feather by feather. Although the immunization effect is better than drinking water immunization, it is very troublesome to operate, while drinking water immunization saves time and effort. At present, many chicken farms generally adopt drinking water immunization for convenience. Especially in the second immunization, but in order to ensure the activity of the vaccine when drinking water immunization, the vaccine must be drunk within 0.5 to 1 hour. Since it is impossible to ensure that all chickens in the flock drink the vaccine water, it is also impossible to distinguish between drinking the vaccine and not drinking it. Therefore, the immunization effect is not sure, and it is very easy to miss the immunization phenomenon, so that the chickens immunized by drinking water will still have different degrees of disease.

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