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Application of quercetin and composition thereof to preparation of anti-hypoxia medicaments

A technology of anti-hypoxic drugs and compositions, applied in the field of medicine, can solve problems such as short lifespan, and achieve the effect of broad application prospects

Inactive Publication Date: 2011-09-14
深圳市药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most free radicals are extremely active in chemical properties and have a short lifespan, but there are also a few free radicals that are very stable in chemical properties, such as 1,1-diphenyl-2-picrylhydrazyl radicals (1,1-diphenyl-2-picrylhydrazyl, DPPH )

Method used

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  • Application of quercetin and composition thereof to preparation of anti-hypoxia medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: tablet

[0060] The composition of each tablet is: quercetin 100mg, lactose 122mg, cornstarch 10% paste 30mg, cornstarch 45mg, magnesium stearate 3mg. First mix quercetin and lactose for 10-15 minutes, and use the prepared cornstarch 10% paste to make the mixture into granules. The wet granules are crushed through a coarse sieve and then dried. The dry granules are sieved and mixed with cornstarch for 10-15 minutes. Add magnesium stearate and mix for 1-3 minutes. The mixture is compressed on a tablet machine into tablets of suitable size and weight.

Embodiment 2

[0061] Embodiment 2: capsules

[0062] The composition of each capsule is: quercetin 100mg, lactose 116mg, corn starch 40mg, magnesium stearate 4mg. First mix quercetin, lactose and cornstarch for 10-15 minutes, then add magnesium stearate and mix for 1-3 minutes. Fill the mixture into suitable sized capsules.

Embodiment 3

[0063] Embodiment 3: tablet

[0064] The composition of each tablet is: quercetin 50mg, chlorogenic acid 25mg, protocatechuic acid 25mg, lactose 122mg, cornstarch 10% paste 30mg, cornstarch 45mg, magnesium stearate 3mg. First mix quercetin, chlorogenic acid, protocatechuic acid and lactose for 10 to 15 minutes, and use the prepared cornstarch 10% paste to make the mixture into granules. The wet granules are crushed through a coarse sieve and then dried. The dry granules are sieved and mixed with cornstarch for 10-15 minutes. Add magnesium stearate and mix for 1-3 minutes. The mixture is compressed on a tablet machine into tablets of suitable size and weight.

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PUM

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Abstract

The invention provides application of quercetin to preparation of anti-hypoxia medicaments. The invention also provides a composition. The composition comprises the quercetin with pharmaceutical effective dose, a pharmaceutically acceptable auxiliary material and chlorogenic acid and / or protocatechuic acid with pharmaceutical effective dose. The quercetin and the quercetin-containing composition can be widely applied to developing and preparing more effective and low-toxicity anti-hypoxia natural medicaments due to the activity in the anti-hypoxia aspect, and have a wide application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to quercetin, a composition containing quercetin and its application in the preparation of anti-hypoxic drugs. Background technique [0002] Oxygen is the first element of human life. Humans can live for weeks without food, days without water, but die within minutes without oxygen. Among all the tissues and organs of the human body, organs such as the brain, heart and lungs need the most oxygen and are most sensitive to the supply of oxygen. When the oxygen content in the air drops to 15-19%, you will feel uncomfortable, have a headache and weakness, and your work efficiency will decrease; if it lasts for 6-12 months, chronic fatigue syndrome, sexual dysfunction or sub-health will appear; if it lasts for 10- 20 years, may develop cancer. When the oxygen content in the air drops to 12-15%, it will cause rapid breathing, rapid heartbeat, poor judgment, and pulmonary edema or cerebral edema ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/216A61K31/192A61K9/20A61K9/48A61P39/00
Inventor 王晓炜王平刘尧曹苹毛羽郑俊霞李军鲁艺王乃利姚新生
Owner 深圳市药品检验所