Preparation method of norfloxacin and glucose injection
A technology for glucose injection and norfloxacin, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of consumption of sodium hydroxide, waste, consumption of hydrochloric acid and the like, To achieve the effect of reducing the amount of sodium hydroxide
Inactive Publication Date: 2012-10-03
HENAN TIANFANG HUAZHONG PHARMA
View PDF0 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0007] When this kind of preparation method is prepared, it is necessary to add hydrochloric acid to dissolve norfloxacin first, and then add sodium hydroxide to reversely adjust the pH value, that is, consume hydrochloric acid and consume sodium hydroxide, resulting in waste and increased production costs
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0019] A preparation method of norfloxacin glucose injection:
[0020] l. Take 50 kg of glucose for injection, dissolve it in 100,000 ml of hot water for injection, add 200 g of activated carbon, heat and boil for 10 to 15 minutes, and filter through a titanium rod.
[0021] 2. Take 1.5 kg of norfloxacin, add 30,000 ml of water for injection and hydrochloric acid, stir to dissolve; then take the remaining 0.5 kg of norfloxacin, add 10,000 ml of water for injection and add sodium hydroxide , stir to dissolve.
[0022] 3. Combine the concentrated solution prepared in step 1 with the concentrated solution prepared in step 2, add 100 grams of activated carbon, add water for injection to 1 million ml, decolorize for 10-15 minutes, and adjust the pH value to 4.0-5.0, Determination of the content of the intermediate product is qualified.
[0023] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention and ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention belongs to the field of pharmaceutical preparations and in particular relates to a preparation method of a norfloxacin and glucose injection. The preparation method comprises the following steps of: (1) preparing concentrated preparation liquid of glucose; (2) preparing the concentrated preparation liquid of norfloxacin, namely, adding 50 to 90 percent of needed norfloxacin into injection liquid of which the amount is 10 to 20 times the amount of the 50 to 90 percent of needed norfloxacin, adding hydrochloric acid into the injection liquid, stirring to dissolve the hydrochloric acid, adding the remaining norfloxacin into the injection liquid of which the amount is 10 to 20 times the amount of the remaining norfloxacin, adding sodium hydroxide into the injection liquid, and stirring to dissolve the sodium hydroxide; and (3) combining the concentrated preparation liquid prepared in step (1) and step (2), adding activated carbon into the mixture to decolour, supplementing water until the amount reaches the total amount, and adjusting the pH value of the mixture to be between 4.0 and 5.0. Through the norfloxacin and glucose injection, the consumption of the hydrochloric acid and the sodium hydroxide can be reduced.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of norfloxacin glucose injection. Background technique [0002] Norfloxacin Glucose Injection is mainly used for the treatment of respiratory tract, urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. [0003] At present, the preparation process of norfloxacin glucose injection, the traditional preparation method is: [0004] 1. Preparation of concentrated glucose solution: take glucose and 10% water for injection and boil for 10-15 minutes, add active ash to decolorize, and filter through a titanium handle to obtain a concentrated solution; [0005] 2. Prepare norfloxacin concentrated solution: take norfloxacin, add 10-20 times the amount of water for injection, add hydrochloric acid, stir to dissolve; [0006] 3. Combine the two concent...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/26A61P31/04
CPCY02A50/30
Inventor 岳臣轩曹志才王晓东赵印铭李新丽李焕巧韩冰
Owner HENAN TIANFANG HUAZHONG PHARMA