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Compound methoxyphenamine quick-release and sustained-release preparation

A technology for compound methoxyphenamine and sustained-release preparations, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, and can solve the problem that compound methoxyphenamine products do not have sustained release, large dosage, and Problems such as taking too many times

Active Publication Date: 2011-10-12
SALUS PHARMA TECH SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent 200410065967.4 discloses a preparation method for oral solid preparations containing methoxypheniramine, narcotine, aminophylline, and chlorpheniramine maleate. The compound methoxyphenamine product obtained by this method does not have sustained release release effect
According to the existing methods of taking medicines on the market, not only the dosage is relatively large, but also the number of takings is many, which is not conducive to ensuring that patients take medicine on time
Long-acting sustained-release preparations can maintain long-term drug effects and can make up for the shortcomings of immediate-release preparations, but simple long-acting sustained-release preparations often have the disadvantage of slow onset of action

Method used

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  • Compound methoxyphenamine quick-release and sustained-release preparation
  • Compound methoxyphenamine quick-release and sustained-release preparation
  • Compound methoxyphenamine quick-release and sustained-release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1: The quick-release-sustained-release compound tablet whose sustained release can reach 12 hours

[0063]

[0064] Preparation Process:

[0065] According to the proportion of the above formula, use dry blending, or dry granulation, or wet granulation process to make the immediate release layer mixture:

[0066] Dry-mixing process preparation method: add active ingredients (methoxyphenamine hydrochloride, narcotine, aminophylline, chlorpheniramine maleate) into cross-linked pyrrolidone and microcrystalline cellulose, and stir evenly; add hard Magnesium fatty acid, stir until uniform to make an immediate-release layer mixture.

[0067] Dry granulation process preparation method: add active ingredients (methoxyphenamine hydrochloride, narcotine, aminophylline, chlorpheniramine maleate) into cross-linked pyrrolidone and microcrystalline cellulose, and stir to form a uniform Mixture, the above-mentioned mixture is extruded into flakes or lumps; then the fla...

Embodiment 2

[0074] Embodiment 2: The quick-release-sustained-release compound tablet whose sustained release can reach 12 hours

[0075] The immediate-release layer of the above-mentioned example 1 was divided into 2 equal parts, and the above-mentioned materials were pressed into three-layer tablets according to the feeding sequence of the immediate-release layer-sustained-release layer-immediate-release layer by using a specific three-layer tablet press;

Embodiment 3

[0076] Embodiment 3: The rapid-release-sustained-release compound tablet whose sustained release can reach 24 hours

[0077]

[0078] Preparation Process:

[0079] According to the proportion of the above formula, use dry blending, or dry granulation, or wet granulation process to make the immediate release layer mixture:

[0080] Dry-mixing process preparation method: add active ingredients (methoxyphenamine hydrochloride, narcotine, aminophylline, chlorpheniramine maleate) into cross-linked pyrrolidone and microcrystalline cellulose, and stir evenly; add hard Magnesium fatty acid, stir until uniform to make an immediate-release layer mixture.

[0081] Dry granulation process preparation method: add active ingredients (methoxyphenamine hydrochloride, narcotine, aminophylline, chlorpheniramine maleate) into cross-linked pyrrolidone and microcrystalline cellulose, and stir to form a uniform Mixture, the above-mentioned mixture is extruded into flakes or lumps; then the fla...

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Abstract

The invention discloses a compound quick-release and sustained-release preparation containing pharmaceutical ingredients including methoxyphenamine or hydrochloride thereof, narcotine, aminophylline and chlorphenamine maleate. A quick-release part contains 1 to 70 percent of active ingredients and a sustained-release part contains 30 to 99 percent of active ingredients. The active ingredients canbe released constantly for 8 to 24 hours. The compound quick-release and sustained-release preparation may be quick-release and sustained-release tablets, quick-release and sustained-release capsulesand quick-release and sustained-release mixed suspensions.

Description

technical field [0001] The present invention relates to a class of drug ingredients containing methoxyphenamine or its hydrochloride, narcotine, aminophylline, chlorpheniramine maleate, 1-70% of which are immediate-release preparations, and 99-30% of which are sustained-release preparations. It is a compound immediate-sustained-release preparation that can be released continuously for 8 to 24 hours. Background technique [0002] Compound methoxyphenamine is an antiasthmatic drug for bronchial asthma and asthmatic bronchitis. Methoxyphenamine hydrochloride suppresses bronchospasm and relieves coughing during an asthma attack. Narcidine is a peripheral antitussive that suppresses coughing. Aminophylline can also inhibit bronchospasm, and also inhibit bronchial mucosal swelling, relieve cough during asthma attack, and make sputum easy to cough up. Chlorpheniramine maleate has antihistamine effects. The compatibility of this product can not only relieve cough caused by throa...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/137A61K31/4741A61K31/4402A61K9/22A61K9/52A61K9/10A61P11/06A61P11/14
CPCA61K9/20A61K9/48A61K31/137A61K31/4402A61K31/4741A61K31/522A61P11/06A61P11/14A61K2300/00
Inventor 田武王诺郑礼亮
Owner SALUS PHARMA TECH SHANGHAI
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