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Preparation method of compound capsule for treating cold

A capsule and compound technology, applied in the field of compound capsule preparation, can solve the problems of simultaneously reaching a therapeutic concentration and maintaining it for a certain period of time, unbalanced release of active pharmaceutical ingredients, and inability to maintain an effective blood drug concentration, thereby improving bioavailability. , The effect of improving medical compliance and convenient use

Active Publication Date: 2012-02-15
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the differences in the absorption and half-life of the above three drugs, the plasma concentration curves of the three drugs are quite different, and the therapeutic concentration cannot be reached at the same or similar time and maintained for a certain period of time. If taken frequently, it may cause the drug with a long half-life to not be eliminated in time, thereby accumulating in the body, resulting in some side effects; the drug with a short half-life cannot maintain the effective blood concentration and fail to achieve the therapeutic effect
[0007] At present, a compound drug containing the active ingredients of the above three drugs has been marketed in the United States. It is a common preparation made by a conventional and traditional preparation process. The absorption and half-life of each drug are different, the release of active ingredients of each drug is uneven, and the drug effect is not ideal

Method used

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Examples

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Effect test

Embodiment 1

[0044] A compound medicine for treating colds, which comprises the following components: in parts by weight, ibuprofen 200g, pseudoephedrine hydrochloride 30g, chlorpheniramine maleate 2g, hydroxypropyl methylcellulose 30g, polyethylene glycol 6000 3g, 50g of cross-linked PVP, 70g of lactose, 0.05g of Tween 80 aqueous solution of 0.04~0.06g / ml and 5g of magnesium stearate; make tablets according to the following steps:

[0045] A. Take 170g of ibuprofen powder, pass the above-mentioned pseudoephedrine hydrochloride powder through a 100-mesh sieve, take 29.85g of hydroxypropyl methylcellulose powder, put it in a fluidized bed of a boiling granulator, mix evenly, and heat to 60-80°C Dissolve the remaining amount of hydroxypropyl methylcellulose in an ethanol solution with a volume percentage of 50% to form a 1% hydroxypropyl methylcellulose solution by mass percentage, and add the 1% hydroxypropyl methylcellulose Vegetable solution is granulated at high speed, and the spraying i...

Embodiment 10

[0051] A compound medicine for treating colds, which comprises the following components: in parts by weight, ibuprofen 100g, pseudoephedrine hydrochloride 17g, chlorpheniramine maleate 1.5g, hydroxypropyl methylcellulose 19g, polyethylene glycol 1.8g of alcohol 6000, 35g of cross-linked PVP, 0.03g of 0.04-0.06g / ml Tween 80 aqueous solution and 2.8g of silicon dioxide; make capsules according to the following steps:

[0052] A. 80g of ibuprofen, pseudoephedrine hydrochloride and 99.95g of hydroxypropyl methylcellulose were crushed through a 100-mesh sieve respectively, mixed evenly with a high-efficiency wet granulator, and 0.05g of hydroxypropylmethylcellulose was dissolved in A 1% hydroxypropyl methylcellulose solution by mass percent is prepared in an ethanol solution with a volume percent of 50%, and the 1% hydroxypropylmethylcellulose solution is added to high-speed granulation, and dried to obtain sustained-release granules;

[0053] B. Mix chlorpheniramine maleate and p...

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Abstract

The invention relates to a preparation process of a compound capsule for treating cold. The compound capsule contains effective dose of active components, namely ibuprofen, pseudoephedrine hydrochloride and chlorphenamine maleate as well as a proper amount of pharmaceutic adjuvant. The preparation process comprises the following steps of: preparing partial effective dose of ibuprofen and pseudoephedrine hydrochloride into a sustained release preparation; preparing allowance of ibuprofen and effective dose of pseudoephedrine hydrochloride into a rapid release preparation; and preparing the sustained release preparation and the rapid release preparation into various medicinal preparations. According to the preparation process disclosed by the invention, a sustained release technology and a rapid release technology are adopted to effectively control the absorption action of three different medical active components in the body, and thus the blood concentrations of the three different medical active components achieve the effective treatment concentration which is consistent with the disappeared time, further the medical effect of the compound medicament is synergically enhanced and the bioavailability of the compound medicament disclosed by the invention is improved.

Description

[0001] This invention is a divisional application of the invention patent with the patent application number 200910191072.8, the application date is October 10, 2009, and the invention name is "a compound medicine for treating colds and its preparation process". technical field [0002] The invention relates to a preparation method of a compound capsule for treating common cold. Background technique [0003] Ibuprofen is an effective prostaglandin synthase inhibitor with antipyretic, analgesic and anti-inflammatory effects; it is almost insoluble in water, but easily soluble in sodium hydroxide or sodium carbonate test solution. It is easy to absorb after oral administration and rectal absorption after administration. Tmax (representing the time taken from taking the medicine to the peak blood concentration) is about 0.92±0.33h. When the dosage is 200mg, the blood concentration is ; When the dosage is 400mg, it is ; When the dosage is 600mg, it is . Half-life T after...

Claims

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Application Information

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IPC IPC(8): A61K31/4402A61K31/192A61K31/137A61K9/52A61P29/00
Inventor 昝琼谈宗华李天泉
Owner TIANSHENG PHARMA GROUP
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