Preparation method of compound capsule for treating cold
A capsule and compound technology, applied in the field of compound capsule preparation, can solve the problems of simultaneously reaching a therapeutic concentration and maintaining it for a certain period of time, unbalanced release of active pharmaceutical ingredients, unable to maintain an effective blood drug concentration, and the like, so as to improve bioavailability. , The effect of improving medical compliance and convenient use
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Embodiment 1
[0044] A compound medicine for treating colds, which comprises the following components: in parts by weight, ibuprofen 200g, pseudoephedrine hydrochloride 30g, chlorpheniramine maleate 2g, hydroxypropyl methylcellulose 30g, polyethylene glycol 6000 3g, 50g of cross-linked PVP, 70g of lactose, 0.05g of Tween 80 aqueous solution of 0.04~0.06g / ml and 5g of magnesium stearate; make tablets according to the following steps:
[0045] A. Take 170g of ibuprofen powder, pass the above-mentioned pseudoephedrine hydrochloride powder through a 100-mesh sieve, take 29.85g of hydroxypropyl methylcellulose powder, put it in a fluidized bed of a boiling granulator, mix evenly, and heat to 60-80°C Dissolve the remaining amount of hydroxypropyl methylcellulose in an ethanol solution with a volume percentage of 50% to form a 1% hydroxypropyl methylcellulose solution by mass percentage, and add the 1% hydroxypropyl methylcellulose Vegetable solution is granulated at high speed, and the spraying i...
Embodiment 10
[0051] A compound medicine for treating colds, which comprises the following components: in parts by weight, ibuprofen 100g, pseudoephedrine hydrochloride 17g, chlorpheniramine maleate 1.5g, hydroxypropyl methylcellulose 19g, polyethylene glycol 1.8g of alcohol 6000, 35g of cross-linked PVP, 0.03g of 0.04-0.06g / ml Tween 80 aqueous solution and 2.8g of silicon dioxide; make capsules according to the following steps:
[0052] A. 80g of ibuprofen, pseudoephedrine hydrochloride and 99.95g of hydroxypropyl methylcellulose were crushed through a 100-mesh sieve respectively, mixed evenly with a high-efficiency wet granulator, and 0.05g of hydroxypropylmethylcellulose was dissolved in A 1% hydroxypropyl methylcellulose solution by mass percent is prepared in an ethanol solution with a volume percent of 50%, and the 1% hydroxypropylmethylcellulose solution is added to high-speed granulation, and dried to obtain sustained-release granules;
[0053] B. Mix chlorpheniramine maleate and p...
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