Compound drug for curing colds and preparation technology thereof

Abstract

The invention relates to a compound drug for curing colds and a preparation technology thereof. The compound drug consists of active components of Ibuprofen, pseudoephedrinehydrochloride, chlorphenamine maleate with effective doses and proper amount of pharmaceutic adjuvants, which is characterized by preparing lbuprofen with a partial effective dose and pseudoephedrinehydrochloride with an effective dose into a sustained-release preparation; preparing ibuprofen with a residual effective dose and chlorphenamine maleate with an effective dose into an immediate-release preparation; and preparing the sustained-release preparation and the immediate-release preparation into various drug preparations according to conventional methods. The invention adopts the sustained-release technology and the immediate-release technology, effectively controls absorption and use of the three different drug active components in vivo, enables the blood concentration of the three drug active components to achieve effective curative concentration and coincidence in decreasing time, thus enhancing the pesticide effect of the compound drug in the invention cooperatively and improving bioavailability of the compound drug in the invention.

Description

technical field

[0001] The invention relates to a compound medicine for treating colds and a preparation process thereof. Background technique

[0002] Ibuprofen is an effective prostaglandin synthase inhibitor with antipyretic, analgesic and anti-inflammatory effects; it is almost insoluble in water, but easily soluble in sodium hydroxide or sodium carbonate test solution. It is easy to absorb after oral administration and rectal absorption after administration. Tmax (representing the time taken from taking the medicine to the peak blood concentration) is about 0.92±0.33h. When the dosage is 200mg, the blood concentration is 22μg / ml~27μg / ml; When the dosage is 23μg / ml~45μg / ml; when the dosage is 600mg, it is 43μg / ml~57μg / ml. Half-life T after one dose 1 / 2 Generally 1.82h.

[0003] Pseudoephedrine hydrochloride has selective vasoconstriction, eliminates congestion and swelling of nasopharyngeal mucosa, relieves symptoms such as nasal congestion, is easily dissolved in wat...