Method for preparing Jingan capsules

Abstract

The invention discloses a method for preparing Jingan capsules. The Jingan capsules are prepared from honeysuckle, common andrographis herb, indigowoad root, dandelion, acetaminophen, amantadinehydrochloride and chlorphenamine maleate. Adopting a secondary drying method during preparation, the method completes drying operation quickly at a low temperature that does not causes component change, makes the particles uniformly dried and the water content reach a standard, makes the particles reach required standards in both properties and various quantized indexes under the condition of ensuring high compactness of the particles of the capsules and meet the requirements of a subsequent process procedure, and ensures the overall quality of the products.

Description

technical field [0001] The invention relates to a method for preparing capsules, in particular to a method for preparing capsules for treating colds (drug name: Jingan Capsules), and belongs to the technical field of pharmacy. Background technique [0002] Flu is a common disease, frequently-occurring disease. The medicine for the treatment of cold in the market is a lot, and they respectively have their own characteristics, but also have their own deficiencies. Therefore, various medicines for treating colds can coexist in the market and be accepted by patients. Jingan Capsule is a kind of capsule for treating cold, which is relatively popular in the market, but there are certain deficiencies in the existing preparation method of Jingan Capsule. After wet granulation, Jingan Capsules are currently dried in a boiling dryer, crushed and blended, and then filled into capsules to make finished products. Due to the relatively high proportion of chemicals in Jingan Capsules an...

AI Technical Summary

Problems solved by technology

Due to the relatively high proportion of chemicals in Jingan Capsules and the presence of (starch) in the excipients, the wet granules produced are relatively viscous and form a cohesive block structure, which is difficult to disperse; it is easy to cause slightly larger blocks The pellets dry unevenly, with low moisture on the outer surface and high moisture inside; the moisture content of the finished pellets is difficult to meet the standard

Furthermore, in the filling process, in order to avoid the impact of the low bulk density on the filling weight difference of Jingan Capsules, the stirring time is usually appropriately increased in the granulation process to make the prepared wet granules have higher compactness; The high density of the particles will affect the drying effect and drying time

And because the proportion of the granular chemicals in this product is relatively high, too high a drying temperature will directly lead to the gelatinization of the chemicals, and even the composition changes; while

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