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Chlorphenamine maleate oral fast dissolving film and preparation method thereof

A technology of chlorpheniramine oral cavity and chlorpheniramine maleate, which is applied in the field of chlorpheniramine maleate oral instant film and its preparation, can solve problems such as inability to take medicine in time and inconvenient carrying of dripping pills, and achieve effective Rapid effect, pleasant taste, and the effect of improving compliance

Inactive Publication Date: 2014-06-18
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Another object of the present invention is to provide a kind of easy to carry, take convenient oral cavity instant film of chlorpheniramine maleate, solve the common dosage form of chlorpheniramine maleate such as tablet, dripping pill to carry inconveniently at present, and the problem of not being able to take the medicine in time without water

Method used

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  • Chlorphenamine maleate oral fast dissolving film and preparation method thereof
  • Chlorphenamine maleate oral fast dissolving film and preparation method thereof
  • Chlorphenamine maleate oral fast dissolving film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Each chlorpheniramine maleate oral instant film contains 4mg of chlorpheniramine maleate, and the composition of every 1000 film formulations is:

[0025]

[0026]

[0027] Specific preparation process:

[0028] Make β-cyclodextrin into a saturated solution, add chlorpheniramine maleate, mix and sonicate for 30 minutes, add sucralose, microcrystalline cellulose, mannitol, stir to disperse evenly, add coloring, essence, 30 % glycerin, 2% hydroxypropyl methylcellulose solution, stirring while adding, stirring and mixing evenly, degassing, that is, chlorpheniramine maleate suspension glue, evenly coated on the flat plate, heating and blasting Dried, cut (2cm*2cm), obtains the chlorpheniramine maleate oral instant film.

[0029] The film is pink in color, has good toughness, dissolves quickly at the entrance, has a bitter taste, and takes 20 seconds to dissolve.

Embodiment 2

[0031] Each chlorpheniramine maleate oral instant film contains 4mg of chlorpheniramine maleate, and the composition of every 1000 film formulations is:

[0032]

[0033] Specific preparation process:

[0034] Take by weighing chlorpheniramine maleate 4g, dissolve with 120mL of water, add polacrilin potassium resin 4g after stirring and dissolving at room temperature, continue stirring and carry out ion exchange 1 hour, obtain chlorpheniramine maleate medicine resin solution, then Add sucralose, pregelatinized starch, and mannitol, stir to disperse evenly, add pigment, essence, 30% glycerin, 2% hydroxypropyl methylcellulose solution, stir while adding, after stirring evenly, remove Gas, the above-mentioned chlorpheniramine maleate suspension glue is evenly coated on the flat plate, heated and blown to dry, cut (2cm * 2cm), obtain the oral cavity instant film of chlorpheniramine maleate.

[0035] The film is pink in color, has good toughness, melts quickly at the entrance, ...

Embodiment 3

[0037] Each chlorpheniramine maleate oral instant film contains 4mg of chlorpheniramine maleate, and the composition of every 1000 film formulations is:

[0038]

[0039] Specific preparation process:

[0040] Take by weighing chlorpheniramine maleate 4g, dissolve with 120mL of water, add polacrilin potassium resin 4g after stirring and dissolving at room temperature, continue stirring and carry out ion exchange 1.5 hours, obtain chlorpheniramine maleate drug resin solution, then Add aspartame, microcrystalline cellulose, sorbitol, stir to disperse evenly, add pigment, essence, 30% glycerin, 1% sodium carboxymethylcellulose solution, stir while adding, after stirring evenly, remove Gas, the above-mentioned chlorpheniramine maleate suspension glue is evenly coated on the flat plate, heated and blown to dry, cut (2cm * 2cm), obtain the oral cavity instant film of chlorpheniramine maleate.

[0041] The film is pink in color, has good toughness, dissolves quickly at the entrance...

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Abstract

The invention belongs to the technical field of medicines, and relates to a chlorphenamine maleate oral fast dissolving film and a preparation method thereof. The chlorphenamine maleate oral fast dissolving film comprises an effective amount of the active component chlorphenamine maleate, an odor mask, a film forming material and a disintegrating agent, and necessary pharmaceutically acceptable filler, sweetener and plasticizer, and a coloring agent and essence both added according to need. The oral fast dissolving film is capable of rapidly disintegrating and dissolving in oral cavity, is good in mouthfeel, fast in drug release speed and rapid in effect onset, and is beneficial for improving medicine compliance of patients especially child patients and elderly patients. Also the oral fast dissolving film is convenient to take, and the problem that medicine taking is not timely in the absence of water is solved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a chlorpheniramine maleate oral instant film and a preparation method thereof, which can rapidly disintegrate in the oral cavity and release the drug, and rapidly absorb and take effect in the gastrointestinal tract after swallowing. Chlorpheniramine maleate oral instant film of the present invention is suitable for skin allergies: urticaria, eczema, dermatitis, drug eruption, pruritus, neurodermatitis, insect bites, solar dermatitis, and can also be used for anaphylaxis Rhinitis, vasomotor rhinitis, drug and food allergies. Background technique [0002] Histamine is a self-active substance widely present in human tissues, with the highest content in mast cells in connective tissue and basophils in blood. Since the discovery of histamine receptors in the 1960s, H1 receptor antagonists have been used to treat allergic diseases. Since the application of the first antihi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4402A61K47/30A61P37/08
Inventor 赵伟卢欣李化淋
Owner 天津市聚星康华医药科技有限公司
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