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Detection device for detection according to surface plasma resonance principle

A technology of surface plasma and detection device, which is applied to measurement device, material analysis by optical means, scattering characteristic measurement, etc., can solve the problems of high instrument construction cost, long sampling time, complicated manufacturing method, etc.

Inactive Publication Date: 2011-11-09
徐坴晖
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For the above two, the production method is complicated and the cost of instrument construction is relatively high
In addition, with the five-step phase-shifting method, five frames need to be captured to calculate a set of meaningful data, and the sampling time is relatively long

Method used

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  • Detection device for detection according to surface plasma resonance principle
  • Detection device for detection according to surface plasma resonance principle
  • Detection device for detection according to surface plasma resonance principle

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Embodiment Construction

[0022] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and understandable, the preferred embodiments of the present invention will be specifically cited below, together with the accompanying drawings, for a detailed description as follows:

[0023] In the following, the basic principle of the present invention, the system architecture of the phase analysis technology, the theoretical analysis and the simulation of the refractive index distribution will be described in sections.

[0024] Fundamental

[0025] The surface plasmon resonance occurs between the dielectric and the metal film, because the photon horizontal polarization component (P polarized light) of the incident light source excites the free electrons of the metal layer to generate longitudinal resonance motion, and this motion is transmitted along the surface of the medium, called Surface Plasmon Wave (Surface Plasmon Wave; SPW). According to the surface...

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Abstract

The invention discloses a detection device for detection according to a surface plasma resonance principle. The device comprises a light source, an optical coupling unit, a phase unwrapping module and a data processing unit, wherein the light source provides a light beam which enters a metal film surface of the optical coupling unit to excite and generate surface plasma resonance; the phase unwrapping module is used for dividing the reflected light of the light beam on the metal film surface into a first path of light, a second path of light, a third path of light and a fourth path of light and detecting the light intensity of each path of light simultaneously; a phase difference between the first path of light and the second path of light is 90 degrees, and a phase difference between the third path of light and the fourth path of light is 90 degrees; and the data processing unit calculates the phase change of the metal film surface subjected to surface plasma resonance according to the light intensity of the first path of light, the second path of light, the third path of light and the fourth path of light.

Description

【Technical field】 [0001] The present invention relates to a detection device for detection based on the principle of surface plasmon resonance, in particular to a detection device for image phase detection based on the principle of surface plasmon resonance. 【Background technique】 [0002] When the biomolecules on the sensor interface interact with the biomolecules to be tested (such as antibodies and antigens), it will cause changes in the physical properties of the interface. This phenomenon can be used to analyze bio-molecular interactions. ) sensing method. With the development and integration of optoelectronic technology and MEMS, a variety of biosensing technologies have been developed, such as Confocal Laser Scanning Fluorescence Microscopy (Confocal Laser Scanning Fluorescence Microscopy; CLSFM), quartz crystal microbalance technology ( Quartz Crystal Micro-balance; QCM), and surface plasmon resonance (SurfacePlasmon Resonance; SPR), etc. Among them, surface plasmo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55G01N21/552
Inventor 徐坴晖
Owner 徐坴晖