Calcium silicon phosphate biomaterial and its preparation method and use

A biomaterial, calcium silicate phosphate technology, used in pharmaceutical formulations, dental preparations, compression mold cups, etc.

Active Publication Date: 2011-12-14
上海积力威尔生物科技合伙企业(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far, the pure phase calcium silicophosphate (Ca 5 (PO 4 ) 2 SiO 4 ) Ceramic materials and preparation methods thereof, especially pure-phase silicon calcium phosphate (Ca 5 (PO 4 ) 2 SiO 4 ) Ceramic materials have not been reported as biomaterials

Method used

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  • Calcium silicon phosphate biomaterial and its preparation method and use
  • Calcium silicon phosphate biomaterial and its preparation method and use
  • Calcium silicon phosphate biomaterial and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0074] (1) Mix 22.4 ml of tetraethyl orthosilicate with 4 ml of nitric acid at a concentration of 2 mol / L, add 9.6 ml of deionized water and 5.8 ml of absolute ethanol, stir at room temperature for 2 hours, then add 34.2 ml of phosphoric acid Triethyl ester, continue to stir for 2 hours, then add 118.1 grams of calcium nitrate tetrahydrate, and stir for 4 hours to obtain a silicon calcium phosphate sol; age the sol at 60°C for 48 hours to obtain a gel; put the gel at 120°C Dry for 120 hours to obtain xerogel;

[0075] (2) Grinding the xerogel into powder, calcining at 1400°C, the heating rate is 2°C / min, and the holding time at 1400°C is 6 hours to obtain silicon calcium phosphate (Ca 5 (PO 4 ) 2 SiO 4 ) powder.

[0076] The prepared powder was subjected to XRD test, and the diffraction peak of the powder was related to Ca 5 (PO 4 ) 2 SiO 4 The standard card (PDF No.40-0393) coincides (such as figure 1 ), indicating that the crystal phase of the synthesized powder is ...

Embodiment 2

[0078] (1) Mix 44.8 milliliters of tetraethyl orthosilicate with 8 milliliters of nitric acid at a concentration of 2 mol / liter, add 19.2 milliliters of deionized water and 11.6 milliliters of absolute ethanol, stir at room temperature for 3 hours, then add 68.4 milliliters of phosphoric acid Triethyl ester, continue to stir for 4 hours, then add 236.2 grams of calcium nitrate tetrahydrate, and stir for 6 hours to obtain a silicon calcium phosphate sol; age the sol at 60°C for 72 hours to obtain a gel; put the gel at 120°C Dry for 168 hours to obtain xerogel;

[0079] (2) Grinding the xerogel into powder, calcining at 1400°C, the heating rate is 2°C / min, and the holding time at 1400°C is 6 hours to obtain silicon calcium phosphate (Ca 5 (PO 4 ) 2 SiO 4 ) powder;

[0080] (3) Grind and sieve the calcium silicon phosphate powder, then weigh 0.2 gram of powder, and dry press it under 8 MPa to form a ceramic green body with a diameter of 10 mm and a thickness of 1 mm; place th...

Embodiment 3

[0083] (1) Mix 44.8 milliliters of tetraethyl orthosilicate with 8 milliliters of nitric acid at a concentration of 2 mol / liter, add 19.2 milliliters of deionized water and 11.6 milliliters of absolute ethanol, stir at room temperature for 3 hours, then add 68.4 milliliters of phosphoric acid Triethyl ester, continue to stir for 4 hours, then add 236.2 grams of calcium nitrate tetrahydrate, and stir for 6 hours to obtain a silicon calcium phosphate sol; age the sol at 60°C for 72 hours to obtain a gel; put the gel at 120°C Dry for 168 hours to obtain xerogel;

[0084] (2) Grinding the xerogel into powder, calcining at 1400°C, the heating rate is 2°C / min, and the holding time at 1400°C is 6 hours to obtain silicon calcium phosphate (Ca 5 (PO 4 ) 2 SiO 4 ) powder;

[0085] (3) Grinding and sieving the silicon calcium phosphate powder, and adding a polyvinyl alcohol aqueous solution with a concentration of 6wt% in the sieved powder, the addition quality of the polyvinyl alcoh...

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Abstract

The invention relates to a calcium phosphate silicate biomaterial, and a preparation method and a purpose thereof. The calcium phosphate silicate biomaterial is characterized in that a soluble silicon source, a soluble phosphor source and a soluble calcium source are used as raw materials, and water is used as a solvent; a sol-gel method is employed to synthesize pure phase calcium phosphate silicate (Ca5(PO4)2SiO4) powder, which is compressed for moulding and sintered into a calcium phosphate silicate (Ca5(PO4)2SiO4) ceramic block. After soaking the Ca5(PO4)2SiO4 ceramic block in a simulated body fluid (SBF) for 1 day, bone-like apatite can be precipitated on a surface of the ceramic block, and the apatite layer becomes thicker with increasing of a soaking time. The Ca5(PO4)2SiO4 prepared in the invention has good biological performance, is a potential biological and medical material and can be used as a bone restoration and filling material and a restoration material in dentistry.

Description

technical field [0001] The present invention relates to silicon calcium phosphate biological material and its preparation method and application, particularly relate to a kind of chemical formula is Ca 5 (PO 4 ) 2 SiO 4 A silicon calcium phosphate biological material belongs to the field of biological materials. Background technique [0002] For biological materials, since calcium phosphate salts have mineral composition and structure similar to vertebrate hard tissues, such as bones and teeth, these materials have been proved to have good biocompatibility no matter what form they are used in. No toxic side effects. However, there are certain deficiencies, for example, hydroxyapatite has good stability in the body, is not easy to be degraded and absorbed, and has low biological activity. Another example is that although tricalcium phosphate ceramics have good biodegradable absorption properties, they also have the problem of low biological activity. [0003] In respons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B35/626C04B35/624A61L27/10A61K6/033A61K6/838
Inventor 宁聪琴鲁文豪
Owner 上海积力威尔生物科技合伙企业(有限合伙)
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