Injectable drug combination and preparation method thereof
A composition and injection technology, which can be used in drug combinations, antipyretics, antitumor drugs, etc., can solve problems such as affecting cardiovascular function, long-term safety inspection of stabilizers and excipients, and reduce potential safety hazards. , good safety, the effect of preventing side effects
Inactive Publication Date: 2012-02-01
SHANGHAI INST OF PHARMA IND
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Abstract
The invention provides an injectable drug combination and a preparation method thereof. The injection preparation which is a freeze-dried powder injection comprises salvianolic acid B and a pharmacologically allowable pH regulator, without other excipients. The addition of the pH regulator is pH being 4-5 in the pre-freeze drying system. The salvianolic acid B injection preparation provided by the invention selects a proper pH range without the addition of a supporting agent to ensure the stabilization of the injection as well as the pharmacological acceptability of the injection. The invention has advantages of safe clinical use, no bad effect of inducing hemolysis, good safety and stable quality for long-term storage with the stability and safety completely meeting the requirement of the injection preparation and the requirement of clinical application. The injection prepared by the technology needs no addition of auxiliary materials such as a stabilizer, a freeze-drying excipient and so on and the hidden danger of the injection is decreased. The invention avoids the use of magnesium salt and the side effect of magnesium ion to cardiovascular system can be prevented.
Application Domain
Organic active ingredientsPowder delivery +12
Technology Topic
Pharmaceutical preservativesSide effect +10
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