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Application of phlorhizin in preparation of drug for treating hyperuricemia

A hyperuricemia and phlorizin technology, applied in the chemical field, can solve the problem of single use of phlorizin, and achieve the effect of reducing uric acid content, strong uric acid level, and lower uric acid level

Active Publication Date: 2012-10-10
温尧林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of application of phlorizin in the preparation of medicine for treating hyperuricemia. Single-purpose technical issues

Method used

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  • Application of phlorhizin in preparation of drug for treating hyperuricemia
  • Application of phlorhizin in preparation of drug for treating hyperuricemia
  • Application of phlorhizin in preparation of drug for treating hyperuricemia

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Embodiment Construction

[0023] The following examples can enable those skilled in the art to understand the present invention more fully, but do not limit the present invention in any way.

[0024] Experimental animals: Kunming mice, 24±2g, male.

[0025] Drug configuration: evenly disperse the natural product phlorizin with a purity of 98% to 100% in normal saline for intragastric administration, with a low dose of 15 mg / kg and a high dose of 60 mg / kg; the positive drug allopurinol 5mg / kg.

[0026] Experimental model: mouse hyperuricemia model.

[0027] Experimental method: 50 Kunming mice were randomly divided into 5 groups, namely blank group, model group, positive drug group, high-dose drug group, and low-dose drug group. Positive drug group, high-dose drug group, and low-dose drug group were administered for 10 days, once a day. One hour after the last administration, except the blank group, the animals in other groups were intraperitoneally injected with 300 mg / kg of oxonic acid potassium sa...

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Abstract

The invention belongs to the field of medicines, discloses application of phlorhizin in preparation of drug for treating hyperuricemia, and also discloses a pharmaceutical composition containing phlorhizin for treating hyperuricemia. The pharmaceutical effective ingredient of the pharmaceutical composition is a monomer compound; and at the same time, animal test shows that the compound has strongaction on lowering mouse in-vivo uric acid content. The hyperuricemia animal model proves that the monomer compound (namely phlorhizin) has strong effect on lowering the uric acid level which is abnormally increased of model animals.

Description

Technical field: [0001] The present invention relates to the field of chemistry, in particular to the new application of dihydrochalcone glycoside monomer compound phlorizin, especially the application of a kind of phlorizin in the preparation of medicine for treating hyperuricemia. Background technique: [0002] Gout is a metabolic disease caused by long-term purine metabolism disorder and increased blood uric acid; hyperuricemia is an important biochemical basis of gout, and it is also a risk factor for many diseases. For example, hyperuricemia can not only induce gouty arthritis, urinary Stone disease, uric acid nephropathy, and elevated blood uric acid levels are closely related to abnormal lipid metabolism, obesity and other diseases. [0003] In the past, the disease was relatively rare in Asians or Orientals, but more common in Europe and the United States. However, since the 1990s, Japan, Taiwan and other regions have developed rapidly, and gout and hyperuricemia hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P19/06
Inventor 温尧林
Owner 温尧林