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Method for extracting tinospora root lactone

A golden fruit and lactone technology, applied in the field of natural medicinal chemistry, can solve the problems of low extraction efficiency, large environmental pollution, poor product quality, etc., and achieve high product quality, less harm to operators and the environment, and less impurity dissolution. Effect

Inactive Publication Date: 2012-03-28
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all use organic reagents to extract, the dosage is large, the extraction efficiency is low, the use of multiple organic reagents, the safety is poor, the environmental pollution is large, and the product quality is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Jin Guolan medicinal material is crushed to 80 mesh, 2kg is placed in the extraction kettle, and liquid CO is introduced 2 And 95% ethanol, flow rate 20L / h, extraction pressure 20MPa, temperature 45℃, extract 3 hours, adjust analysis temperature 50℃, pressure 6MPa conditions, collect the extract to recover ethanol, add 300g neutral alumina (particle size 200 -300 mesh) dry, crushed and packed into a short column, take 1.2L 90% ethanol for elution, collect the eluate and concentrate close to 200ml for crystallization, filter out and recrystallize with 80% ethanol solution, and dry to obtain 61 g of echinacea, content 84% (UV method).

Embodiment 2

[0018] Jin Guolan medicinal material is crushed to 60 mesh, 2kg is placed in the extraction kettle, and liquid CO is introduced 2 And 99% ethanol, flow rate 25L / h, extraction pressure 25MPa, temperature 55℃, extraction for 2 hours, adjust analysis temperature 60℃, pressure 10MPa conditions, collect the extract to recover ethanol, add 400g neutral alumina (particle size 200 -300 mesh) dry, pulverize and pack into short column, take 1.5L 95% ethanol for elution, collect the eluate and concentrate close to 300ml for crystallization, filter out and recrystallize with 90% ethanol solution, and dry to obtain 48g of echinacea, content 91% (UV method).

Embodiment 3

[0020] Jin Guolan medicinal material is crushed to 40 mesh, 2kg is placed in the extraction kettle, and liquid CO is introduced 2 And 95% ethanol, flow rate 30L / h, extraction pressure 23MPa, temperature 50℃ for 3 hours, adjust analysis temperature 55℃, pressure 8MPa conditions, collect the extract to recover ethanol, add 300g neutral alumina (particle size 200 -300 mesh) dry, crushed and packed into a short column, take 1L of 95% ethanol for elution, collect the eluate and concentrate close to 200ml for crystallization, filter out and recrystallize with 90% ethanol solution, dry to obtain 53g of echinacea, content 86 % (UV method).

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Abstract

The invention discloses a method for extracting tinospora root lactone. The method comprises the following steps of: a, smashing a tinospora medicinal material to 40-80 meshes, putting into an extracting kettle, introducing liquid CO2 and an entrainer under the extracting pressure 20-25 MPa and at the temperature 45-55 DEG C, extracting at the flow speed 20-30 L / h for 2-3 hours, and resolving to obtain an extraction liquid; and b, recovering a reagent from the extraction liquid, adding alumina for drying, loading onto a short column, eluting with a 90-95 percent ethanol solution, concentrating the eluent to small volume for crystallizing, recrystallizing a crystal with an ethanol solution, and drying to obtain the tinospora root lactone. The method has the characteristics of high efficiency, short period and environmental friendliness, and is suitable for industrial production.

Description

Technical field [0001] The invention belongs to the field of natural medicinal chemistry, and particularly relates to a method for extracting echinaceone. Background technique [0002] Radix Tinosporae (Radix Tinosporae) is the root tuber of the tetragonaceae plant ox gall, also called Dikudan, Shan Cigu, Jiu Niu gall and herring gall. The nature and taste are bitter and cold, and it has the effects of clearing away heat, detoxifying, relieving throat and relieving pain. It is used for sore throat, carbuncle and furuncle, diarrhea, dysentery, fever and pain in the abdomen. Studies have shown that the main medicinal components of Alkaloids and lactones are contained in Jin Guolan, among which the content of lactones is more, and the antibacterial and anti-inflammatory effects are significant. [0003] Most of the existing processes for extracting lactone components from Golden Fruits are leaching with organic reagents and then using macroporous resins or extraction methods to sepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/18
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH