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Antihypertensive medicinal composition

A composition and drug technology, applied in the direction of drug combination, cardiovascular system diseases, etc., can solve the problems of high treatment cost, large side effects, large blood pressure fluctuations, etc., and achieve the goal of reducing vascular resistance, improving quality of life, and enhancing therapeutic effect Effect

Inactive Publication Date: 2012-04-04
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to overcome the deficiencies of the prior art, especially the defects of high treatment cost, large side effects and large fluctuation of blood pressure in the process of lowering blood pressure, the present invention provides a novel pharmaceutical composition for treating hypertension. The pharmaceutical composition uses azelnidipine or its pharmaceutically acceptable salt and fimasartan as the active ingredients. The advantages of the pharmaceutical composition for the treatment of hypertension are clear ingredients, comprehensive effects, less stimulation to the cardiovascular and cerebrovascular vessels, and fewer side effects. , enabling a smooth step-down

Method used

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  • Antihypertensive medicinal composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of Azedipine Fimasartan Compound Tablet

[0026] Azedipine 8g

[0027] Fimasartan 0.8g

[0028] Compressible starch 120g

[0029] Cyclodextrin 10g

[0030] Sodium carboxymethyl starch 10g

[0031] Magnesium stearate 0.6g

[0032] 5% PVP in absolute ethanol solution

[0033] Preparation process: First, put Azeldipine and cyclodextrin into a mortar, grind and mix evenly, then add sodium carboxymethyl starch and compressible starch and mix evenly, finally add Fimasartan and mix evenly, and use 5% PVP Anhydrous ethanol solution is used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0034] Embodiment 2 Preparation of Azeldipine Fimasartan Compound Tablet

[0035] Azedipine 8g

[0036] Fimasartan 8g

[0037] Compressible starch 130g

[0038] Cyclodextrin 10g

[0039] Sodium carboxymethyl starch 10g

[0040] Magnesium stearate 0.6g

[0041] 5% PVP in absolute ethanol solution

[0042] Preparation process: First, put Azeldipine and cyclodextrin into a mortar, grind and mix evenly, then add sodium carboxymethyl starch and compressible starch and mix evenly, finally add Fimasartan and mix evenly, and use 5% PVP Anhydrous ethanol solution is used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0043] Embodiment 3 Preparation of Azeldipine Fimasartan Compound Tablet

[0044] Azedipine 0.1g

[0045] Fimasartan 50g

[0046] Microcrystalline Cellulose 150g

[0047] β-cyclodextrin 10g

[0048] Sodium carboxymethyl starch 15g

[0049] Micronized silica gel 0.8g

[0050] Preparation process: First, put Azedipine and β-cyclodextrin into a mortar, grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, micropowder silica gel and mix evenly, finally add Fimasartan and mix evenly, The powder can be directly compressed into tablets.

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Abstract

The invention which discloses an antihypertensive medicinal composition and concretely relates to a medicinal composition containing azelnidipine or a pharmaceutically acceptable salt thereof and fimasartan belongs to the medicinal field. In the antihypertensive medicinal composition, the weight ratio of azelnidipine or the pharmaceutically acceptable salt thereof to fimasartan is 1:0.1-500, and preferably 1:1-50. The azelnidipine fimasartan medicinal composition of the invention, which has the advantages of obvious synergism, low treatment cost, small side effect and realization of stationary blood pressure reduction when the composition is used to treat hypertension, has a good clinical application prospect.

Description

technical field [0001] The present invention relates to an antihypertensive pharmaceutical composition and its use, in particular, to a pharmaceutical composition with azendipine or its pharmaceutically acceptable salt and fimasartan as active ingredients, and its preparation of antihypertensive Use in high blood pressure medications. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and it is also one of the largest epidemics. It often causes complications in the heart, brain, kidney and other organs, and seriously endangers human health. Early prevention and timely treatment are of great significance, and the research and development of drugs for the treatment of cardiovascular diseases has become one of the hot spots in the field of medical research. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medica...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K31/4427A61P9/12
Inventor 赵志全王洪臣
Owner LUNAN PHARMA GROUP CORPORATION
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