Unlock instant, AI-driven research and patent intelligence for your innovation.

Chinese medicinal composition for treating keloids and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of preparation of traditional Chinese medicine compositions, can solve the problem of no complete cure for keloids and the like, and achieve the effects of significant treatment of keloids, no toxic and side effects, and convenient use.

Inactive Publication Date: 2013-06-12
HEFEI UNIV OF TECH +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is currently no cure for keloids.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese medicinal composition for treating keloids and preparation method thereof
  • Chinese medicinal composition for treating keloids and preparation method thereof
  • Chinese medicinal composition for treating keloids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] Taking macroporous adsorption resin adsorption separation as an example, non-limiting examples are described as follows.

[0038] 1. Preparation of Astragalus total saponins:

[0039] Astragalus is crushed and extracted with 80% ethanol for 3 times under reflux, 8 times the amount of ethanol each time, refluxed for 3 hours each time, the extracts are combined for 3 times, distilled under reduced pressure, the ethanol is recovered and concentrated until there is no alcohol smell, and the concentrated solution is added with water Appropriate amount of solution is applied to the aqueous solution on a D101 macroporous adsorption resin column to absorb and separate total astragalus saponins, elute with water, 30%, and 70% ethanol respectively, collect the 70% ethanol eluate and recover ethanol under reduced pressure, and place the concentrated solution at 60°C under reduced pressure Dried to obtain total astragalus saponins extract.

[0040] Taking astragaloside IV as the r...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Chinese medicinal composition for treating keloids and a preparation method thereof. The Chinese medicinal composition for treating the keloids consists of an astragalus total saponin active fraction, a salvianolic acid active fraction and a total tanshinone active fraction in the mass ratio of (0.5-5):(10-50):(1-8), wherein the mass content of astragalus total saponins in the astragalus total saponin active fraction is not less than 50 percent; the mass content of salvianolic acids in the salvianolic acid active fraction is not less than 50 percent; and the mass content of total tanshinones in the total tanshinone active fraction is not less than 50 percent. As proved by in-vitro pharmacodynamic study, the capability of the Chinese medicinal composition for remarkably suppressing fibroblast proliferation, collagen synthesis and invasive migration of human keloids stimulated by a transforming growth factor beta1 (TGF-beta1) plays an important role in preventing and treating the keloids.

Description

1. Technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating keloids and a preparation method thereof. 2. Background technology [0002] Keloid is a pathological wound healing process after skin injury, and its most notable feature is the excessive deposition of extracellular matrix (ECM) components produced by continuous activation of fibroblasts, especially collagen, leading to dermal fibrosis. Skin damage can be secondary to acne, folliculitis, ear piercing, burns, or surgery, among others. Unlike hypertrophic scars that are limited to the original wound area, keloid lesions obviously exceed the scope of the original injury, and the edges are often crab-like, invasive growth to the surrounding tissue, and generally do not degenerate and contracture, so it is considered a A benign tumor of the skin. Keloids can occur on the skin of the whole ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61K36/537A61P17/02
Inventor 张霄翔杨雁何淑芳杨森张学军
Owner HEFEI UNIV OF TECH