Diosmin-containing medicinal composition

A technology of diosmin and its composition, which is applied in the field of pharmaceutical compositions containing diosmin, can solve problems such as blood in the stool and pain symptoms without obvious effect, achieve significant therapeutic effect, good stability, and improve curative effect Effect

Inactive Publication Date: 2012-04-25
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN200610000675.1 discloses a suppository composed of micronized diosmin and hesperidin, which improves the bioavailability a

Method used

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  • Diosmin-containing medicinal composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of tablets

[0021] 1. Prescription (1000 tablets)

[0022]

[0023] 2. Experimental steps:

[0024] (1) Pulverization: Diosmin, ryuflavin, and borneol were pulverized to obtain particle sizes of 0.5 μm, 0.5 μm, and 1 μm, respectively.

[0025] (2) Granulation: Weigh 500g of crushed diosmin, 200g of salixin, 40g of microcrystalline cellulose, 40g of silicon dioxide, use cross-linked polyvinylpyrrolidone as a binder, and wet granulate. A 24-mesh sieve, dried at 65°C, granulated, added 60 g of borneol and 3 g of magnesium stearate, and mixed well.

[0026] (3) Tableting: get the tablet core.

[0027] (4) Coating: Film-coating the tablet core to obtain film-coated tablets.

Embodiment 2

[0028] Example 2 Preparation of tablets

[0029] 1. Prescription (1000 tablets)

[0030]

[0031] 2. Experimental steps:

[0032] (1) Pulverization: Diosmin, ryuflavin, and borneol were pulverized to obtain particle sizes of 10 μm, 10 μm, and 20 μm, respectively.

[0033] (2) Granulation: Weigh 100g of pulverized diosmin, 100g of salixin, 15g of microcrystalline cellulose, 15g of silicon dioxide, 0.5% sodium carboxymethyl starch solution as a binder, and wet process The granules are passed through a 24-mesh sieve, dried at 60°C, and granulated, 50 g of borneol and 1 g of magnesium stearate are added, and mixed evenly.

[0034] (3) Tableting: get the tablet core.

[0035] (4) Coating: Film-coating the tablet core to obtain film-coated tablets.

Embodiment 3

[0036] Example 3 Preparation of capsules

[0037] 1. Prescription (1000 capsules)

[0038]

[0039] 2. Experimental steps:

[0040] (1) Pulverization: Diosmin, ryuflavin, and borneol were pulverized to obtain particle sizes of 0.5 μm, 0.5 μm, and 1 μm, respectively.

[0041] (2) Granulation: Weigh 100g of pulverized diosmin, 100g of salixin, 25g of microcrystalline cellulose, 30g of silicon dioxide, and use 1% sodium carboxymethyl starch solution as binder, and prepare by wet method The granules are passed through a 24-mesh sieve, dried at 70°C, and granulated, 50 g of borneol and 2 g of magnesium stearate are added, and mixed evenly.

[0042] (3) Filling: get capsules.

[0043] (4) Packing, ready to go.

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Abstract

The invention relates to a diosmin-containing medicinal composition, which has beneficial effect to treatment of hemorrhoids, in particular a remarkable treatment effect to hematochezia and pains caused by internal hemorrhoids, by means of combination of diosmin, pectolinarigenin and borneol. The diosmin-containing medicinal composition has the advantages of good stability, high bioavailability and simple preparation process, and is suitable for large-scale industrial production.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating hemorrhoids, in particular to a pharmaceutical composition containing diosmin, and belongs to the technical field of medicine. Background technique [0002] Hemorrhoids are one or more soft venous clusters formed by varicose veins at the bottom of the anorectum and anal mucosa, including internal hemorrhoids, external hemorrhoids and mixed hemorrhoids. [0003] Hemorrhoids is a common anorectal disease in clinic, with a high incidence, accounting for 87.25% of all anorectal diseases. The existing methods for treating hemorrhoids are mainly surgical treatment and drug treatment. Although the surgical treatment is more thorough, the patient is more painful and may relapse. Therefore, the most commonly used method is drug treatment, and most hemorrhoids treatment drugs are mainly for external hemorrhoids. In clinical practice, internal hemorrhoids are the most common, accounting for 52.19% of ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/045A61P9/14
Inventor 田舟山袁红波
Owner NANJING CHIA TAI TIANQING PHARMA
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