Desmethylvenlafaxine sustained-release pellet and preparation method thereof
A technology of sustained-release pellets and venlafaxine, which can be applied to pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems that there are no sustained-release pellets
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Embodiment 1
[0028] Embodiment 1 desvenlafaxine sustained-release pellets and tablets (1000 preparation units)
[0029] The prescription of preparation and preparation method thereof are:
[0030] prescription
[0031] Pellets:
[0032]
[0033] Tablets:
[0034] Eudragit L100 24g
[0035] Microcrystalline Cellulose 12g
[0037] Preparation:
[0038] Get the desvenlafaxine raw material and pass through an 80-mesh sieve for subsequent use. Take povidone and add 80% alcohol to dissolve, and use it as a binder for later use; ethyl cellulose, triethyl citrate, polyethylene glycol, add ethanol or acetone and dissolve it, and use it as a slow-release coating solution for later use;
[0039] Take blank pellet cores, put them in a coating pan or a centrifugal coating granulator, spray povidone ethanol solution as a binder, add desvenlafaxine powder, and make pellets. Spray into the sustained-release coating solution, wrap the pellets with a sustained-rele...
Embodiment 2
[0043] Embodiment 2 Desvenlafaxine sustained-release pellets and tablets (1000 preparation units)
[0044] prescription
[0045] Pellets:
[0046]
[0047] Tablets:
[0048]
[0049] Preparation:
[0050] Get the desvenlafaxine raw material and pass through an 80-mesh sieve for subsequent use. Take povidone and add 80% ethanol to dissolve, and use it as a binder for later use; hydroxypropyl methylcellulose E50, triethyl citrate, polyethylene glycol and add ethanol or acetone to dissolve it, and use it as a slow-release coating solution for later use;
[0051] Get the blank ball core, put it in the coating pot or in the centrifugal coating granulator, spray into the povidone ethanol solution as the binding agent, add desvenlafaxine powder, and make micropills. Spray into the sustained-release coating solution, wrap the pellets with a sustained-release film, and dry for 1 hour after coating. Then dry at 40° C. for 12 hours to obtain sustained-release pellets.
[005...
Embodiment 3
[0055] Embodiment 3 desvenlafaxine sustained-release pellets and tablets (1000 preparation units)
[0056] prescription
[0057] Ball core:
[0058] Desvenlafaxine 20g
[0060] Povidone 5g
[0061] Pellets:
[0062] Ball core
[0063]
[0064] Tablets:
[0065] Microcrystalline Cellulose 12g
[0066] Ethyl cellulose 10g
[0068] Preparation:
[0069] Get the desvenlafaxine raw material and pass through an 80-mesh sieve for subsequent use. Get the main drug of the prescription amount of the ball core, and dissolve povidone with 80% ethanol, and use it as an adhesive for standby; mix the main drug and sucrose powder evenly and add the adhesive to prepare the ball core;
[0070] Dissolve hydroxypropyl methylcellulose E50, triethyl citrate, propylene glycol with ethanol or acetone, and use it as a slow-release coating solution for later use; take the core containing pills, put them in a coating pan or a centri...
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