Bispecific egfr/igfir binding molecules

An IGF-IR, binding technology, applied in the direction of peptide/protein components, growth factors/inducible factors, anti-receptors/cell surface antigens/cell surface determinant immunoglobulins, etc.
CN102439036AInactive Publication Date: 2012-05-02BRISTOL MYERS SQUIBB CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BRISTOL MYERS SQUIBB CO
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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Description

[0001] sequence listing

[0002] This application contains a Sequence Listing that has been submitted via the EFS Network and is hereby incorporated by reference in its entirety. Said ASCII copy, created on November 23, 2009, is named COTH52WO.txt and is 552,529 bytes in size.

[0003] related application

[0004] This application claims U.S. Provisional Patent Application Nos. 61 / 200,164, filed November 24, 2008; 61 / 200,282, filed November 26, 2008; 61 / 212,966, filed April 17, 2009; May 14, 2009 61 / 178,279 filed; and 61 / 227,330 filed July 21, 2009, which are hereby incorporated by reference in their entirety.

[0005] introduce

[0006] The present invention relates to EGFR binding domains and bispecific molecules comprising an EGFR binding domain and a unique IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and vec...

Claims

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